Effects of 6-12 months of esomeprazole treatment on the gastric mucosa

Robert M. Genta, Guido Rindi, Roberto Fiocca, David J. Magner, Donald D'Amico, Douglas S. Levine

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: The aim of this study was to determine the effect of 6-12 months of treatment with esomeprazole on the histopathology of the gastric mucosa. METHODS: Two identically designed, randomized, placebo-controlled trials of esomeprazole 40, 20, or 10 mg daily for up to 6 months, as well as a noncomparative, multicenter trial of esomeprazole 40 mg daily for up to 12 months, were conducted in 1326 patients with healed erosive esophagitis (1294 negative for Helicobacter pylori [H. pylori]). Gastric biopsy samples were obtained before treatment and on completion of (or discontinuation from) the trials. Samples were evaluated for the presence of H. pylori, characteristics of acute gastritis or atrophic gastritis, and enterochromaffin-like cell pathology. RESULTS: During treatment with esomeprazole, the number of patients with an improvement in gastric histological scores was typically greater than or equal to the number who worsened. Gastric histological scores worsened for each corporal or antral characteristic of gastritis in

Original languageEnglish
Pages (from-to)1257-1265
Number of pages9
JournalAmerican Journal of Gastroenterology
Issue number6
Publication statusPublished - Jun 1 2003

ASJC Scopus subject areas

  • Gastroenterology


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