Effects of 6-aminochrysene on liver microsomal enzyme activity

R. Russo, I. Bartošek, S. Villa, A. Guaitani, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

1. No transformation of 6-aminochrysene took place during its incubation with rat liver microsomes under oxygen or anaerobic conditions. 2. 6-Aminochrysene inhibited the hydroxylation of aniline, O-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. 3. Pre-treatment of rats with 6-aminochrysene markedly decreased the N-demethylation in vitro but significantly increased the hydroxylation and the O-demethylation. Similar effects were observed also with microsomal preparations from livers perfused with 6-aminochrysene.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalXenobiotica
Volume6
Issue number4
DOIs
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology
  • Biochemistry
  • Health, Toxicology and Mutagenesis
  • Biochemistry, Genetics and Molecular Biology(all)

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