Effects of a 16-week progressive high-intensity strength training (HIST) on indexes of bone turnover in men over 65 years: A randomized controlled study

The aim of the present study was to evaluate the effects of a 16-week progressive high-intensity strength training (HIST) program on peripheral markers of bone turnover (bone Gla protein, BGP; bone alkaline phosphatase, B-AP; N-terminal propeptide of type I procollagen, PINP; C-terminal cross-linked telopeptide of type I collagen, ICTP) in healthy, elderly men over 65 yr of age. Thirty healthy men (aged 65-81 yr), performing light to moderate daily physical activity, were randomly divided into two groups. Group 1 (no.=16) followed a supervised 16-week progressive HIST program, while subjects of group 2 (no.=14), used as controls, were requested to maintain their habitual level of physical activity for 16 weeks. HIST program consisted of 6 different sets of exercise (2 involving the major muscle groups of the lower limb and 4 involving those of the upper limb). Three sessions/week, during which 10 repetitions of each exercise set were completed, were performed. Lower limb exercises shifted from 50 to 80% of the one maximal repetition (1MR) during the first month of the protocol and were thereafter maintained at an intensity of 80% 1MR throughout the training. Upper limb exercises shifted from 40 to 65% of 1MR with a similar pattern. All sessions were preceded by 15 min of cycloergometer exercise at 50% of maximal oxygen uptake and by a warm-up of 15 repetitions at 20% of 1MR of each exercise set. The HIST program did not significantly change BGP (mean±SE, before: 15.6±1.2 μg/l vs after: 16.0±1.2 μg/l, NS) and PINP levels (before: 44.6±6.7 μg/l vs after: 43.1±6.0 μg/l, NS). On the contrary, serum B-AP significantly increased (before: 50.2±6.1 IU/l vs after: 62.3±7.0 IU/l, p