Effects of a 3-month dietary intervention with a lacto-ovo-vegetarian diet on Vitamin B 12 levels in a group of omnivores: Results from the CARDIVEG (Cardiovascular Prevention with Vegetarian Diet) study

M. Dinu, G. Pagliai, F. Cesari, B. Giusti, A. M. Gori, R. Marcucci, A. Casini, F. Sofi

Research output: Contribution to journalArticle

Abstract

Previous studies have suggested that vegetarianism can result in a reduction of vitamin B12 circulating levels. The aim of the present study was to investigate the effects of a 3-month dietary intervention with a lacto-ovo-vegetarian diet (VD) on the levels of circulating vitamin B12 in a group of omnivores. We analysed fifty-four omnivorous subjects who followed a VD as a first dietary intervention within the CARDIVEG (Cardiovascular Prevention with Vegetarian Diet) study, a dietary intervention study. VD resulted in a significant reduction (P<0·001) of 51·2 % of vitamin B12 intake and in a significant reduction (P=0·005) of 6·2 % of the circulating levels of vitamin B12 (-24·5 pg/ml). Changes in vitamin B12 intake were significantly correlated with changes in circulating levels of vitamin B12 (R 0·61, P<0·001). Subgroup analyses showed that reduction in circulating vitamin B12 levels was more evident in participants who were younger, overweight, non-smokers and had hypercholesterolaemia. A logistic regression analysis showed that a reduction in vitamin B12 intake greater than the first quartile of the delta changes obtained in the study population (-28·5 %) conferred a significantly higher risk of experiencing a decrease in circulating vitamin B12 levels (OR 10·1; 95 % CI 1·3, 76·1). In conclusion, a 3-month VD period determined a significant reduction in circulating levels of vitamin B12, being significantly correlated with the reduction in vitamin B12 intake. Although a well-planned VD can provide adequate nutrition across all life stages, special care must be taken to ensure adequate vitamin B12 intake and to help prevent deficiency.

Original languageEnglish
Pages (from-to)756-762
Number of pages7
JournalBritish Journal of Nutrition
Volume121
Issue number7
DOIs
Publication statusPublished - Apr 14 2019

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Vegetarian Diet
Vitamin B 12
Vegetarians
Hypercholesterolemia

Keywords

  • Vegetarian diet: Vitamin B12: Clinical trials: Dietary intervention

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effects of a 3-month dietary intervention with a lacto-ovo-vegetarian diet on Vitamin B 12 levels in a group of omnivores : Results from the CARDIVEG (Cardiovascular Prevention with Vegetarian Diet) study. / Dinu, M.; Pagliai, G.; Cesari, F.; Giusti, B.; Gori, A. M.; Marcucci, R.; Casini, A.; Sofi, F.

In: British Journal of Nutrition, Vol. 121, No. 7, 14.04.2019, p. 756-762.

Research output: Contribution to journalArticle

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abstract = "Previous studies have suggested that vegetarianism can result in a reduction of vitamin B12 circulating levels. The aim of the present study was to investigate the effects of a 3-month dietary intervention with a lacto-ovo-vegetarian diet (VD) on the levels of circulating vitamin B12 in a group of omnivores. We analysed fifty-four omnivorous subjects who followed a VD as a first dietary intervention within the CARDIVEG (Cardiovascular Prevention with Vegetarian Diet) study, a dietary intervention study. VD resulted in a significant reduction (P<0·001) of 51·2 {\%} of vitamin B12 intake and in a significant reduction (P=0·005) of 6·2 {\%} of the circulating levels of vitamin B12 (-24·5 pg/ml). Changes in vitamin B12 intake were significantly correlated with changes in circulating levels of vitamin B12 (R 0·61, P<0·001). Subgroup analyses showed that reduction in circulating vitamin B12 levels was more evident in participants who were younger, overweight, non-smokers and had hypercholesterolaemia. A logistic regression analysis showed that a reduction in vitamin B12 intake greater than the first quartile of the delta changes obtained in the study population (-28·5 {\%}) conferred a significantly higher risk of experiencing a decrease in circulating vitamin B12 levels (OR 10·1; 95 {\%} CI 1·3, 76·1). In conclusion, a 3-month VD period determined a significant reduction in circulating levels of vitamin B12, being significantly correlated with the reduction in vitamin B12 intake. Although a well-planned VD can provide adequate nutrition across all life stages, special care must be taken to ensure adequate vitamin B12 intake and to help prevent deficiency.",
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AU - Sofi, F.

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