Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables: A dietary intervention study

F. Sofi, A. Buccioni, F. Cesari, A. M. Gori, S. Minieri, L. Mannini, A. Casini, G. F. Gensini, R. Abbate, M. Antongiovanni

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aim: Some studies recently reported a favourable effect for cis-9, trans-11 conjugated linoleic acid (CLA) on plasma lipoprotein profile of healthy subjects. Aim of this crossover intervention study was to evaluate the influence of a short-term dietary intake of a cheese derived from sheep's milk naturally rich in CLA on several atherosclerotic biomarkers, in comparison with a commercially available cheese. Methods and results: Ten subjects (6 F; 4 M) with a median age of 51.5 followed for 10 weeks a diet containing 200 g/week of cheese naturally rich in CLA (intervention period) and for the same period a diet containing a commercially available cheese of the same quantity (placebo period). Consumption of the dairy product naturally rich in cis-9, trans-11 CLA determined a significant (p <0.05) reduction in inflammatory parameters such as interleukin-6 (pre: 8.08 ± 1.57 vs. post: 4.58 ± 0.94 pg/mL), interleukin-8 (pre: 45.02 ± 5.82 vs. post: 28.59 ± 2.64 pg/mL), and tumour necrosis factor-α (pre: 53.58 ± 25.67 vs. post: 32.09 ± 17.42 pg/mL) whereas no significant differences in the placebo period were observed. With regard to haemorheological parameters, the test period significantly ameliorated erythrocytes' filtration rate (pre: 7.61 ± 0.71% vs. post: 9.12 ± 0.97%; p = 0.03) with respect to the placebo period. Moreover, a reduction in the extent of platelet aggregation, induced by arachidonic acid [pre: 87.8 ± 1.76% vs. post: 77.7 ± 3.56%; p = 0.04] was observed during the test period in comparison with the placebo period. Conclusions: Dietary short-term intake of the tested dairy product naturally rich in cis-9, trans-11 CLA appeared to cause favourable biochemical changes of atherosclerotic markers.

Original languageEnglish
Pages (from-to)117-124
Number of pages8
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Cardiovascular disease
  • Dairy products
  • Diet
  • Haemorheology
  • Inflammation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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