Effects of a diet with inulin-enriched pasta on gut peptides and gastric emptying rates in healthy young volunteers

Francesco Russo, Caterina Clemente, Michele Linsalata, Marisa Chiloiro, Antonella Orlando, Emanuele Marconi, Guglielmina Chimienti, Giuseppe Riezzo

Research output: Contribution to journalArticlepeer-review


Aim Our group has previously shown that the administration of pasta enriched along with the prebiotic inulin induces a significant reduction in triglyceride and glucose levels with a significant delay in gastric emptying (GE) rates. This protective effect may occur by affecting the release of a number of gut peptides involved in the control of gastrointestinal motility. The aim of the present study was to evaluate the effects of inulin-enriched pasta on the circulating levels of neurotensin (NT), somatostatin (SS), and corticotropin-releasing factor (CRF) in relation to the GE time in young healthy subjects. Methods Twenty healthy young male volunteers completed a randomized double-blind crossover study consisting of a 2-week run-in period and two 5-week study periods (11% inulin-enriched/control pasta), with an 8-week wash-out period in between. Gut peptide concentrations were evaluated by radioimmunoassay. GE time was evaluated by ultrasonography. Results The prebiotic treatment significantly increased the area under the curve (AUC) values of both NT and SS (p

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalEuropean Journal of Nutrition
Issue number4
Publication statusPublished - Jun 2011


  • Corticotropin-releasing factor
  • Diet
  • Fibre
  • Gastric emptying
  • Gut peptides
  • Inulin
  • Metabolic syndrome
  • Neurotensin
  • Somatostatin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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