Effects of a gamma aminobutyric acid (GABA) derivative, baclofen, on growth hormone and prolactin secretion in man

F. Cavagnini, C. Invitti, A. Di Landro, L. Tenconi, C. Maraschini, G. Girotti

Research output: Contribution to journalArticle

Abstract

In 2 groups of 6 normal subjects each, the authors have investigated the effects of oral administration of a gamma aminobutyric acid (GABA) derivative, baclofen [β-(4-chlorophenyl)-gamma aminobutyric acid, Lioresal, Ciba-Geigy] on growth hormone (GH) and prolactin (PRL) secretion in response to insulin hypoglycemia and arginine infusion, respectively. Administration of baclofen, 30 mg daily for 4 days, caused a significant reduction of GH response to hypoglycemia (mean peak values decreased from 30.7 ± 6.30 to 21.5 ± 5.74 ng/ml, P

Original languageEnglish
Pages (from-to)579-584
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume45
Issue number3
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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