Effects of a gluten-containing meal on gastric emptying and gallbladder contraction

Sara Massironi, Federica Branchi, Mirella Fraquelli, Alessandra Baccarin, Francesco Somalvico, Francesca Ferretti, Dario Conte, Luca Elli

Research output: Contribution to journalArticle

Abstract

The ingestion of gluten has been associated with gastrointestinal symptoms even in the absence of detectable immune responses. Little is known about the pathophysiological effects of gluten on the upper gastrointestinal tract. We aimed to assess whether the ingestion of gluten leads to an impairment of the physiological mechanisms of gastric emptying, gallbladder contraction and relaxation. A total of 17 healthy subjects underwent ultrasound evaluation of gastric emptying dynamics and gallbladder contractions at baseline and every 30 min after a standard gluten-containing and gluten-free meal (250 kcal, 70% carbohydrates). The pattern of gastric emptying was similar after a standard meal with or without gluten, but differed in terms of the peak of the antral filling curve, which was wider (mean area 5.69, median 4.70, range 3.71-9.27 cm2 vs. mean 4.89, median 4.57, 2.27-10.22 cm2, p = 0.023) after the gluten-containing meal. The pattern of gallbladder contractions was different after the gluten-free meal (p < 0.05), with higher gallbladder volumes in the late refilling phases. The results of this study show that gluten ingestion exerts objective effects on gastric and gallbladder motility. Although the underlying pathophysiological mechanism remains unknown, these results could account for some of the gluten-related symptoms reported by patients with celiac disease and non-celiac gluten sensitivity.

Original languageEnglish
Article number910
JournalNutrients
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 16 2018

Fingerprint

gastric emptying
Glutens
gall bladder
Gastric Emptying
Gallbladder
gluten
Meals
Eating
ingestion
signs and symptoms (animals and humans)
Upper Gastrointestinal Tract
celiac disease
Celiac Disease
gastrointestinal system
Stomach
Healthy Volunteers
stomach
Carbohydrates
immune response
carbohydrates

Keywords

  • Celiac disease
  • Cholecyst
  • Gastric emptying
  • Gluten
  • Non celiac gluten sensitivity

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Effects of a gluten-containing meal on gastric emptying and gallbladder contraction. / Massironi, Sara; Branchi, Federica; Fraquelli, Mirella; Baccarin, Alessandra; Somalvico, Francesco; Ferretti, Francesca; Conte, Dario; Elli, Luca.

In: Nutrients, Vol. 10, No. 7, 910, 16.07.2018.

Research output: Contribution to journalArticle

Massironi, Sara ; Branchi, Federica ; Fraquelli, Mirella ; Baccarin, Alessandra ; Somalvico, Francesco ; Ferretti, Francesca ; Conte, Dario ; Elli, Luca. / Effects of a gluten-containing meal on gastric emptying and gallbladder contraction. In: Nutrients. 2018 ; Vol. 10, No. 7.
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