Abstract
Administration of high doses of a kinin antagonist produces an increase in blood pressure. Thus, endogenous klnins may be involved in the regulation of blood pressure. Kinins can induce the release of vasoactive substances such as catecholamines, renin, vasopressin, histamine, and prostaglandins. To determine whether the blood pressure changes induced by high doses of kinin antagonist are due to agonistic activity mediated by these vasoactive substances, we studied the effect on blood pressure of a kinin antagonist (DArg0-Hyp3-Thi5,8-DPtie7-bradyklnln) administered to control, nephrectomized, and adrenalectomized rats, and to rats treated with vasopressin V1-receptor antagonist, ganglionic and α and β-adrenergic receptor blockers (either separately or combined), H1- and H2-receptor blockers, and indomethacin, a prostaglandin synthesis inhibitor. Blood pressure changes were monitored on awake, restrained rats. In the control rat, the kinin antagonist injected as a bolus (4 mg/kg) into the ascending aorta produced a transient biphasic blood pressure response, first a pressor effect (ΔBP=7 ± 1 mm Hg; p <0.05), then a depressor effect (ΔBP=-20 ± 6 mm Hg; p <0.05). The pressor response to the kinin antagonist was not affected by any of the treatments; however, the depressor effect of the kinin antagonist appeared to be caused by the release of vasodilator prostanoids from the kidney, since it was not observed in the nephrectomized rats or in those treated with indomethacin. The pressor effect induced by the kinin antagonist suggests that kinins may contribute to the regulation of blood pressure.
| Original language | English |
|---|---|
| Pages (from-to) | I-84-I-88 |
| Journal | Hypertension |
| Volume | 11 |
| Issue number | 2 |
| Publication status | Published - 1988 |
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Keywords
- Blood pressure regulation
- Bradykinin
- Depressor
- Kinin antagonist
- Pressor
ASJC Scopus subject areas
- Internal Medicine
Cite this
Effects of a kinin antagonist on mean blood pressure. / Carbonell, Luis F.; Carretero, Oscar A.; Madeddu, Paolo; Scicli, A. Guillermo.
In: Hypertension, Vol. 11, No. 2, 1988, p. I-84-I-88.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of a kinin antagonist on mean blood pressure
AU - Carbonell, Luis F.
AU - Carretero, Oscar A.
AU - Madeddu, Paolo
AU - Scicli, A. Guillermo
PY - 1988
Y1 - 1988
N2 - Administration of high doses of a kinin antagonist produces an increase in blood pressure. Thus, endogenous klnins may be involved in the regulation of blood pressure. Kinins can induce the release of vasoactive substances such as catecholamines, renin, vasopressin, histamine, and prostaglandins. To determine whether the blood pressure changes induced by high doses of kinin antagonist are due to agonistic activity mediated by these vasoactive substances, we studied the effect on blood pressure of a kinin antagonist (DArg0-Hyp3-Thi5,8-DPtie7-bradyklnln) administered to control, nephrectomized, and adrenalectomized rats, and to rats treated with vasopressin V1-receptor antagonist, ganglionic and α and β-adrenergic receptor blockers (either separately or combined), H1- and H2-receptor blockers, and indomethacin, a prostaglandin synthesis inhibitor. Blood pressure changes were monitored on awake, restrained rats. In the control rat, the kinin antagonist injected as a bolus (4 mg/kg) into the ascending aorta produced a transient biphasic blood pressure response, first a pressor effect (ΔBP=7 ± 1 mm Hg; p <0.05), then a depressor effect (ΔBP=-20 ± 6 mm Hg; p <0.05). The pressor response to the kinin antagonist was not affected by any of the treatments; however, the depressor effect of the kinin antagonist appeared to be caused by the release of vasodilator prostanoids from the kidney, since it was not observed in the nephrectomized rats or in those treated with indomethacin. The pressor effect induced by the kinin antagonist suggests that kinins may contribute to the regulation of blood pressure.
AB - Administration of high doses of a kinin antagonist produces an increase in blood pressure. Thus, endogenous klnins may be involved in the regulation of blood pressure. Kinins can induce the release of vasoactive substances such as catecholamines, renin, vasopressin, histamine, and prostaglandins. To determine whether the blood pressure changes induced by high doses of kinin antagonist are due to agonistic activity mediated by these vasoactive substances, we studied the effect on blood pressure of a kinin antagonist (DArg0-Hyp3-Thi5,8-DPtie7-bradyklnln) administered to control, nephrectomized, and adrenalectomized rats, and to rats treated with vasopressin V1-receptor antagonist, ganglionic and α and β-adrenergic receptor blockers (either separately or combined), H1- and H2-receptor blockers, and indomethacin, a prostaglandin synthesis inhibitor. Blood pressure changes were monitored on awake, restrained rats. In the control rat, the kinin antagonist injected as a bolus (4 mg/kg) into the ascending aorta produced a transient biphasic blood pressure response, first a pressor effect (ΔBP=7 ± 1 mm Hg; p <0.05), then a depressor effect (ΔBP=-20 ± 6 mm Hg; p <0.05). The pressor response to the kinin antagonist was not affected by any of the treatments; however, the depressor effect of the kinin antagonist appeared to be caused by the release of vasodilator prostanoids from the kidney, since it was not observed in the nephrectomized rats or in those treated with indomethacin. The pressor effect induced by the kinin antagonist suggests that kinins may contribute to the regulation of blood pressure.
KW - Blood pressure regulation
KW - Bradykinin
KW - Depressor
KW - Kinin antagonist
KW - Pressor
UR - http://www.scopus.com/inward/record.url?scp=0023951512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023951512&partnerID=8YFLogxK
M3 - Article
C2 - 3346068
AN - SCOPUS:0023951512
VL - 11
SP - I-84-I-88
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 2
ER -