Effects of a leukotriene receptor antagonist on exhaled leukotriene E 4 and prostanoids in children with asthma

Paolo Montuschi, Chiara Mondino, Pierluigi Koch, Peter J. Barnes, Giovanni Ciabattoni

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Leukotriene (LT) E 4 and 8-isoprostane concentrations are elevated in exhaled breath condensate in children with asthma. The effects of leukotriene receptor antagonists (LTRAs) on exhaled leukotriene and prostanoids in children with asthma are unknown. Objective: (1) To study the effect of montelukast, a LTRA, on exhaled LTE 4, 8-isoprostane, and prostaglandin E 2 in children with asthma and atopic children; (2) to measure exhaled nitric oxide. Methods: An open-label study with oral montelukast (5 mg once daily for 4 weeks) was undertaken in 17 atopic children with asthma and 16 atopic children without asthma. Results: Pretreatment exhaled LTE 4 (P <.0001) and 8-isoprostane (P <.0001) values were higher in atopic children with asthma than in atopic children without asthma. In atopic children with asthma, montelukast reduced exhaled LTE 4 by 33% (P <.001), and this reduction was correlated with pretreatment LTE 4 values (r = -0.90; P = .0001). Posttreatment exhaled LTE 4 levels in children with asthma were higher than pretreatment LTE 4 values in atopic children without asthma (P <.004). Montelukast had no effect on exhaled LTE 4 in atopic children without asthma (P = .74), or on exhaled 8-isoprostane (atopic children with asthma, P = .94; atopic children without asthma, P = .55) and PGE 2 (atopic children with asthma, P = .56; atopic children without asthma, P = .93) in both groups. In atopic children with asthma, exhaled nitric oxide concentrations were reduced by 27% (P <.05) after montelukast. Conclusion: Leukotriene receptor antagonists decrease exhaled LTE 4 in atopic children with asthma. This reduction is dependent on baseline exhaled LTE 4 values. Clinical implications: Measurement of exhaled LTE 4 might help identify children with asthma most likely to benefit from LTRAs.

Original languageEnglish
Pages (from-to)347-353
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume118
Issue number2
DOIs
Publication statusPublished - Aug 2006

Keywords

  • airway inflammation
  • childhood asthma
  • exhaled breath condensate
  • exhaled nitric oxide
  • Leukotriene E
  • leukotriene receptor antagonists
  • noninvasive markers
  • prostanoids

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Effects of a leukotriene receptor antagonist on exhaled leukotriene E 4 and prostanoids in children with asthma'. Together they form a unique fingerprint.

Cite this