Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style

Emma Jane Rose, April Hargreaves, Derek Morris, Ciara Fahey, Daniela Tropea, Elizabeth Cummings, Carlo Caltagirone, Paola Bossù, Chiara Chiapponi, Fabrizio Piras, Gianfranco Spalletta, Michael Gill, Aiden Corvin, Gary Donohoe

Research output: Contribution to journalArticle

Abstract

Background: A single nucleotide polymorphism (rs7914558) within the cyclin M2 (CNNM2) gene was recently identified as a common risk variant for schizophrenia. The mechanism by which CNNM2 confers risk is unknown. Aims: To determine the impact of the rs7914558 risk 'A' allele on measures of neurocognition, social cognition and brain structure. Method: Patients with schizophrenia (n = 400) and healthy controls (n = 160) completed measures of neuropsychological function and social cognition. Structural magnetic resonance imaging data were also acquired from an overlapping sample of Irish healthy controls (n = 159) and an independent sample of Italian patients (n = 82) and healthy controls (n = 39). Results: No effects of genotype on neuropsychological test performance were observed. However, a dosage effect of the risk allele was found for an index of social cognition (i.e. attributional style), such that risk status was associated with reduced self-serving bias across groups (GG>AG>AA, Pcorrected

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalBritish Journal of Psychiatry
Volume204
Issue number2
DOIs
Publication statusPublished - Feb 2014

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Rose, E. J., Hargreaves, A., Morris, D., Fahey, C., Tropea, D., Cummings, E., Caltagirone, C., Bossù, P., Chiapponi, C., Piras, F., Spalletta, G., Gill, M., Corvin, A., & Donohoe, G. (2014). Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style. British Journal of Psychiatry, 204(2), 115-121. https://doi.org/10.1192/bjp.bp.113.131359