Effects of a nutraceutical combination of monacolin, g-oryzanol and g-aminobutyric acid on lipid profile and C-reactive protein in mice

Giuseppe Derosa, Pamela Maffioli, Angela D’Angelo, Rosario Russo

Research output: Contribution to journalArticle

Abstract

Introduction: The aim of this study was to evaluate the efficacy of two nutraceutical agents aimed to improve lipid profile in a sample of mice. Material and methods: Fifty mice were randomly divided into four groups. Control mice were fed a standard diet (SD), while the other three groups were fed with a high-fat diet (HFD) for 4 weeks. At the end of the run-in period, mice fed with the SD continued to follow the SD, while mice fed with the HFD were divided into three groups: one continued with the HFD, one continued to follow the HFD + a blend of natural components derived from rice and fermented rice (monacolin K 3%, g-oryzanol, and g-aminobutyric acid) (S1), and the other one followed the HFD + one nutraceutical containing monacolin K 3% alone for 24 weeks. Results: The results showed that mice treated with HFD + S1 and HFD + S2 had lower levels of TC compared to mice fed with the HFD alone (p < 0.01, and p < 0.05, respectively). Moreover, mice treated with HFD + S1 had lower TC and LDL-C levels compared to mice fed with HFD + S2 (p < 0.05). Mice treated with HFD + S1 or S2 had lower Tg levels compared to mice fed with the HFD (p < 0.05). Conclusions: We can conclude that a combination of monacolin K 3%, g-oryzanol, and g-aminobutyric acid is more effective than monacolin K 3% alone in reducing the negative effects of a HFD in a sample of specific pathogen-free mice.

Original languageEnglish
Pages (from-to)792-796
Number of pages5
JournalArchives of Medical Science
Volume15
Issue number4
DOIs
Publication statusPublished - Jan 1 2019

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Aminobutyrates
High Fat Diet
Dietary Supplements
C-Reactive Protein
Lipids
Lovastatin
Diet
gamma-oryzanol
Specific Pathogen-Free Organisms

Keywords

  • Diet
  • Lipid profile
  • Mice
  • Monacolin K
  • Nutraceutical

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of a nutraceutical combination of monacolin, g-oryzanol and g-aminobutyric acid on lipid profile and C-reactive protein in mice. / Derosa, Giuseppe; Maffioli, Pamela; D’Angelo, Angela; Russo, Rosario.

In: Archives of Medical Science, Vol. 15, No. 4, 01.01.2019, p. 792-796.

Research output: Contribution to journalArticle

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