Effects of a series of new synthetic high polymers on cancer metastases

P. Ferruti, F. Danusso, G. Franchi, N. Polentarutti, S. Garattini

Research output: Contribution to journalArticle

Abstract

Sixteen new synthetic high polymers were studied for a possible effect on the dissemination of cancer cells from Sarcoma 180 implanted intracerebrally (ic). The efficacy in reducing the formation of lung metastases form Lewis lung carcinoma implanted intramuscularly (im) and of lymphnodal metastases from Ehrlich carcinoma implanted intratibially (it) was also determined after treatment with the polymeric substances. Some compounds tested showed almost the same activity, in the same experimental conditions, of several well-known antitumor agents, such as, for instance, cyclophosphamide and Triton WR 1339. The structure of most of the polymers is such that they may show simultaneously both cationic and tensioactive properties. The structure-activity relationship is discussed and a suggestion is made concerning the properties of polymers which should be taken into account when designing new macromolecular drugs with a potential antimetastatic activity.

Original languageEnglish
Pages (from-to)496-499
Number of pages4
JournalJournal of Medicinal Chemistry
Volume16
Issue number5
Publication statusPublished - 1973

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ASJC Scopus subject areas

  • Organic Chemistry

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