Abstract
Hypoxemia is common in diabetes, and reflex responses to hypoxia are blunted. These abnormalities could lead to cardiovascular/ renal complications. Interval hypoxia (IH) (5-6 short periods of hypoxia each day over 1-3 weeks) was successfully used to improve the adaptation to hypoxia in patients with chronic obstructive pulmonary disease. We tested whether IH over 1 day could initiate a long-lasting response potentially leading to better adaptation to hypoxia. In 15 patients with type 1 diabetes, we measured hypoxic and hypercapnic ventilatory responses (HCVRs), ventilatory recruitment threshold (VRT-CO2), baroreflex sensitivity (BRS), blood pressure, and blood lactate before and after 0, 3, and 6 h of a 1-h single bout of IH. All measurements were repeated on a placebo day (single-blind protocol, randomized sequence). After IH (immediately and after 3 h), hypoxic and HCVR increased, whereas the VRT-CO2 dropped. No such changes were observed on the placebo day. Systolic and diastolic blood pressure increased, whereas blood lactate decreased after IH. Despite exposure to hypoxia, BRS remained unchanged. Repeated exposures to hypoxia over 1 day induced an initial adaptation to hypoxia, with improvement in respiratory reflexes. Prolonging the exposure to IH (.2 weeks) in type 1 diabetic patients will be a matter for further studies.
| Original language | English |
|---|---|
| Pages (from-to) | 4220-4227 |
| Number of pages | 8 |
| Journal | Diabetes |
| Volume | 62 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2013 |
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ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Effects of a single bout of interval hypoxia on cardiorespiratory control in patients with type 1 diabetes. / Duennwald, Tobias; Bernardi, Luciano; Gordin, Daniel; Sandelin, Anna; Syreeni, Anna; Fogarty, Christopher; Kytö, Janne P.; Gatterer, Hannes; Lehto, Markku; Hörkkö, Sohvi; Forsblom, Carol; Burtscher, Martin; Groop, Per Henrik.
In: Diabetes, Vol. 62, No. 12, 12.2013, p. 4220-4227.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of a single bout of interval hypoxia on cardiorespiratory control in patients with type 1 diabetes
AU - Duennwald, Tobias
AU - Bernardi, Luciano
AU - Gordin, Daniel
AU - Sandelin, Anna
AU - Syreeni, Anna
AU - Fogarty, Christopher
AU - Kytö, Janne P.
AU - Gatterer, Hannes
AU - Lehto, Markku
AU - Hörkkö, Sohvi
AU - Forsblom, Carol
AU - Burtscher, Martin
AU - Groop, Per Henrik
PY - 2013/12
Y1 - 2013/12
N2 - Hypoxemia is common in diabetes, and reflex responses to hypoxia are blunted. These abnormalities could lead to cardiovascular/ renal complications. Interval hypoxia (IH) (5-6 short periods of hypoxia each day over 1-3 weeks) was successfully used to improve the adaptation to hypoxia in patients with chronic obstructive pulmonary disease. We tested whether IH over 1 day could initiate a long-lasting response potentially leading to better adaptation to hypoxia. In 15 patients with type 1 diabetes, we measured hypoxic and hypercapnic ventilatory responses (HCVRs), ventilatory recruitment threshold (VRT-CO2), baroreflex sensitivity (BRS), blood pressure, and blood lactate before and after 0, 3, and 6 h of a 1-h single bout of IH. All measurements were repeated on a placebo day (single-blind protocol, randomized sequence). After IH (immediately and after 3 h), hypoxic and HCVR increased, whereas the VRT-CO2 dropped. No such changes were observed on the placebo day. Systolic and diastolic blood pressure increased, whereas blood lactate decreased after IH. Despite exposure to hypoxia, BRS remained unchanged. Repeated exposures to hypoxia over 1 day induced an initial adaptation to hypoxia, with improvement in respiratory reflexes. Prolonging the exposure to IH (.2 weeks) in type 1 diabetic patients will be a matter for further studies.
AB - Hypoxemia is common in diabetes, and reflex responses to hypoxia are blunted. These abnormalities could lead to cardiovascular/ renal complications. Interval hypoxia (IH) (5-6 short periods of hypoxia each day over 1-3 weeks) was successfully used to improve the adaptation to hypoxia in patients with chronic obstructive pulmonary disease. We tested whether IH over 1 day could initiate a long-lasting response potentially leading to better adaptation to hypoxia. In 15 patients with type 1 diabetes, we measured hypoxic and hypercapnic ventilatory responses (HCVRs), ventilatory recruitment threshold (VRT-CO2), baroreflex sensitivity (BRS), blood pressure, and blood lactate before and after 0, 3, and 6 h of a 1-h single bout of IH. All measurements were repeated on a placebo day (single-blind protocol, randomized sequence). After IH (immediately and after 3 h), hypoxic and HCVR increased, whereas the VRT-CO2 dropped. No such changes were observed on the placebo day. Systolic and diastolic blood pressure increased, whereas blood lactate decreased after IH. Despite exposure to hypoxia, BRS remained unchanged. Repeated exposures to hypoxia over 1 day induced an initial adaptation to hypoxia, with improvement in respiratory reflexes. Prolonging the exposure to IH (.2 weeks) in type 1 diabetic patients will be a matter for further studies.
UR - http://www.scopus.com/inward/record.url?scp=84891766935&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891766935&partnerID=8YFLogxK
U2 - 10.2337/db13-0167
DO - 10.2337/db13-0167
M3 - Article
C2 - 23733200
AN - SCOPUS:84891766935
VL - 62
SP - 4220
EP - 4227
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 12
ER -