Effects of a single bout of interval hypoxia on cardiorespiratory control in patients with type 1 diabetes

Tobias Duennwald, Luciano Bernardi, Daniel Gordin, Anna Sandelin, Anna Syreeni, Christopher Fogarty, Janne P. Kytö, Hannes Gatterer, Markku Lehto, Sohvi Hörkkö, Carol Forsblom, Martin Burtscher, Per Henrik Groop

Research output: Contribution to journalArticle

Abstract

Hypoxemia is common in diabetes, and reflex responses to hypoxia are blunted. These abnormalities could lead to cardiovascular/ renal complications. Interval hypoxia (IH) (5-6 short periods of hypoxia each day over 1-3 weeks) was successfully used to improve the adaptation to hypoxia in patients with chronic obstructive pulmonary disease. We tested whether IH over 1 day could initiate a long-lasting response potentially leading to better adaptation to hypoxia. In 15 patients with type 1 diabetes, we measured hypoxic and hypercapnic ventilatory responses (HCVRs), ventilatory recruitment threshold (VRT-CO2), baroreflex sensitivity (BRS), blood pressure, and blood lactate before and after 0, 3, and 6 h of a 1-h single bout of IH. All measurements were repeated on a placebo day (single-blind protocol, randomized sequence). After IH (immediately and after 3 h), hypoxic and HCVR increased, whereas the VRT-CO2 dropped. No such changes were observed on the placebo day. Systolic and diastolic blood pressure increased, whereas blood lactate decreased after IH. Despite exposure to hypoxia, BRS remained unchanged. Repeated exposures to hypoxia over 1 day induced an initial adaptation to hypoxia, with improvement in respiratory reflexes. Prolonging the exposure to IH (.2 weeks) in type 1 diabetic patients will be a matter for further studies.

Original languageEnglish
Pages (from-to)4220-4227
Number of pages8
JournalDiabetes
Volume62
Issue number12
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Type 1 Diabetes Mellitus
Baroreflex
Blood Pressure
Hypoxia
Reflex
Lactic Acid
Placebos
Chronic Obstructive Pulmonary Disease

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Duennwald, T., Bernardi, L., Gordin, D., Sandelin, A., Syreeni, A., Fogarty, C., ... Groop, P. H. (2013). Effects of a single bout of interval hypoxia on cardiorespiratory control in patients with type 1 diabetes. Diabetes, 62(12), 4220-4227. https://doi.org/10.2337/db13-0167

Effects of a single bout of interval hypoxia on cardiorespiratory control in patients with type 1 diabetes. / Duennwald, Tobias; Bernardi, Luciano; Gordin, Daniel; Sandelin, Anna; Syreeni, Anna; Fogarty, Christopher; Kytö, Janne P.; Gatterer, Hannes; Lehto, Markku; Hörkkö, Sohvi; Forsblom, Carol; Burtscher, Martin; Groop, Per Henrik.

In: Diabetes, Vol. 62, No. 12, 12.2013, p. 4220-4227.

Research output: Contribution to journalArticle

Duennwald, T, Bernardi, L, Gordin, D, Sandelin, A, Syreeni, A, Fogarty, C, Kytö, JP, Gatterer, H, Lehto, M, Hörkkö, S, Forsblom, C, Burtscher, M & Groop, PH 2013, 'Effects of a single bout of interval hypoxia on cardiorespiratory control in patients with type 1 diabetes', Diabetes, vol. 62, no. 12, pp. 4220-4227. https://doi.org/10.2337/db13-0167
Duennwald T, Bernardi L, Gordin D, Sandelin A, Syreeni A, Fogarty C et al. Effects of a single bout of interval hypoxia on cardiorespiratory control in patients with type 1 diabetes. Diabetes. 2013 Dec;62(12):4220-4227. https://doi.org/10.2337/db13-0167
Duennwald, Tobias ; Bernardi, Luciano ; Gordin, Daniel ; Sandelin, Anna ; Syreeni, Anna ; Fogarty, Christopher ; Kytö, Janne P. ; Gatterer, Hannes ; Lehto, Markku ; Hörkkö, Sohvi ; Forsblom, Carol ; Burtscher, Martin ; Groop, Per Henrik. / Effects of a single bout of interval hypoxia on cardiorespiratory control in patients with type 1 diabetes. In: Diabetes. 2013 ; Vol. 62, No. 12. pp. 4220-4227.
@article{e2ef5f16bc474700922100c04bbab107,
title = "Effects of a single bout of interval hypoxia on cardiorespiratory control in patients with type 1 diabetes",
abstract = "Hypoxemia is common in diabetes, and reflex responses to hypoxia are blunted. These abnormalities could lead to cardiovascular/ renal complications. Interval hypoxia (IH) (5-6 short periods of hypoxia each day over 1-3 weeks) was successfully used to improve the adaptation to hypoxia in patients with chronic obstructive pulmonary disease. We tested whether IH over 1 day could initiate a long-lasting response potentially leading to better adaptation to hypoxia. In 15 patients with type 1 diabetes, we measured hypoxic and hypercapnic ventilatory responses (HCVRs), ventilatory recruitment threshold (VRT-CO2), baroreflex sensitivity (BRS), blood pressure, and blood lactate before and after 0, 3, and 6 h of a 1-h single bout of IH. All measurements were repeated on a placebo day (single-blind protocol, randomized sequence). After IH (immediately and after 3 h), hypoxic and HCVR increased, whereas the VRT-CO2 dropped. No such changes were observed on the placebo day. Systolic and diastolic blood pressure increased, whereas blood lactate decreased after IH. Despite exposure to hypoxia, BRS remained unchanged. Repeated exposures to hypoxia over 1 day induced an initial adaptation to hypoxia, with improvement in respiratory reflexes. Prolonging the exposure to IH (.2 weeks) in type 1 diabetic patients will be a matter for further studies.",
author = "Tobias Duennwald and Luciano Bernardi and Daniel Gordin and Anna Sandelin and Anna Syreeni and Christopher Fogarty and Kyt{\"o}, {Janne P.} and Hannes Gatterer and Markku Lehto and Sohvi H{\"o}rkk{\"o} and Carol Forsblom and Martin Burtscher and Groop, {Per Henrik}",
year = "2013",
month = "12",
doi = "10.2337/db13-0167",
language = "English",
volume = "62",
pages = "4220--4227",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "12",

}

TY - JOUR

T1 - Effects of a single bout of interval hypoxia on cardiorespiratory control in patients with type 1 diabetes

AU - Duennwald, Tobias

AU - Bernardi, Luciano

AU - Gordin, Daniel

AU - Sandelin, Anna

AU - Syreeni, Anna

AU - Fogarty, Christopher

AU - Kytö, Janne P.

AU - Gatterer, Hannes

AU - Lehto, Markku

AU - Hörkkö, Sohvi

AU - Forsblom, Carol

AU - Burtscher, Martin

AU - Groop, Per Henrik

PY - 2013/12

Y1 - 2013/12

N2 - Hypoxemia is common in diabetes, and reflex responses to hypoxia are blunted. These abnormalities could lead to cardiovascular/ renal complications. Interval hypoxia (IH) (5-6 short periods of hypoxia each day over 1-3 weeks) was successfully used to improve the adaptation to hypoxia in patients with chronic obstructive pulmonary disease. We tested whether IH over 1 day could initiate a long-lasting response potentially leading to better adaptation to hypoxia. In 15 patients with type 1 diabetes, we measured hypoxic and hypercapnic ventilatory responses (HCVRs), ventilatory recruitment threshold (VRT-CO2), baroreflex sensitivity (BRS), blood pressure, and blood lactate before and after 0, 3, and 6 h of a 1-h single bout of IH. All measurements were repeated on a placebo day (single-blind protocol, randomized sequence). After IH (immediately and after 3 h), hypoxic and HCVR increased, whereas the VRT-CO2 dropped. No such changes were observed on the placebo day. Systolic and diastolic blood pressure increased, whereas blood lactate decreased after IH. Despite exposure to hypoxia, BRS remained unchanged. Repeated exposures to hypoxia over 1 day induced an initial adaptation to hypoxia, with improvement in respiratory reflexes. Prolonging the exposure to IH (.2 weeks) in type 1 diabetic patients will be a matter for further studies.

AB - Hypoxemia is common in diabetes, and reflex responses to hypoxia are blunted. These abnormalities could lead to cardiovascular/ renal complications. Interval hypoxia (IH) (5-6 short periods of hypoxia each day over 1-3 weeks) was successfully used to improve the adaptation to hypoxia in patients with chronic obstructive pulmonary disease. We tested whether IH over 1 day could initiate a long-lasting response potentially leading to better adaptation to hypoxia. In 15 patients with type 1 diabetes, we measured hypoxic and hypercapnic ventilatory responses (HCVRs), ventilatory recruitment threshold (VRT-CO2), baroreflex sensitivity (BRS), blood pressure, and blood lactate before and after 0, 3, and 6 h of a 1-h single bout of IH. All measurements were repeated on a placebo day (single-blind protocol, randomized sequence). After IH (immediately and after 3 h), hypoxic and HCVR increased, whereas the VRT-CO2 dropped. No such changes were observed on the placebo day. Systolic and diastolic blood pressure increased, whereas blood lactate decreased after IH. Despite exposure to hypoxia, BRS remained unchanged. Repeated exposures to hypoxia over 1 day induced an initial adaptation to hypoxia, with improvement in respiratory reflexes. Prolonging the exposure to IH (.2 weeks) in type 1 diabetic patients will be a matter for further studies.

UR - http://www.scopus.com/inward/record.url?scp=84891766935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891766935&partnerID=8YFLogxK

U2 - 10.2337/db13-0167

DO - 10.2337/db13-0167

M3 - Article

C2 - 23733200

AN - SCOPUS:84891766935

VL - 62

SP - 4220

EP - 4227

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 12

ER -