Effects of a wheat germ-enriched diet on skeletal muscle regeneration

C. Rizzi, R. Chignola, G. Zoccatelli, M. Donà, A. D B Peruffo, U. Carraro, K. Rossini

Research output: Contribution to journalArticle

Abstract

One of the common ingredients used in dietary supplements is wheat germ and its derivatives. In this study the effect of a wheat germ-enriched diet (WGED) on tissue repair was investigated in a model of skeletal muscle damage induced by the anesthetic bupivacaine. Rats were fed normal feedstuff or a WGED; injections of bupivacaine caused skeletal muscle necrosis followed by tissue regeneration. Morphometric analyses were performed on the muscles in order to quantify cell size and nuclei migration toward the cell periphery because these are indices of muscle regeneration. Statistical analysis shows that myoblast maturation, determined by nuclei migration to a peripheral position, was significantly delayed in rats fed wged compared to rats fed the control diet. No statistically significant differences were observed in the myocellular areas. This study provides evidence that dietary wheat germ can interfere with muscle regeneration.

Original languageEnglish
Pages (from-to)417-425
Number of pages9
JournalItalian Journal of Food Science
Volume15
Issue number3
Publication statusPublished - 2003

Fingerprint

wheat germ
muscle development
Triticum
skeletal muscle
Regeneration
Skeletal Muscle
Diet
Bupivacaine
tissue repair
diet
Muscles
rats
Cell Nucleus Size
myoblasts
Myoblasts
Dietary Supplements
cell movement
anesthetics
Cell Movement
dietary supplements

Keywords

  • Lectins
  • Muscle regeneration
  • Myofibers
  • Wheat germ

ASJC Scopus subject areas

  • Food Science

Cite this

Rizzi, C., Chignola, R., Zoccatelli, G., Donà, M., Peruffo, A. D. B., Carraro, U., & Rossini, K. (2003). Effects of a wheat germ-enriched diet on skeletal muscle regeneration. Italian Journal of Food Science, 15(3), 417-425.

Effects of a wheat germ-enriched diet on skeletal muscle regeneration. / Rizzi, C.; Chignola, R.; Zoccatelli, G.; Donà, M.; Peruffo, A. D B; Carraro, U.; Rossini, K.

In: Italian Journal of Food Science, Vol. 15, No. 3, 2003, p. 417-425.

Research output: Contribution to journalArticle

Rizzi, C, Chignola, R, Zoccatelli, G, Donà, M, Peruffo, ADB, Carraro, U & Rossini, K 2003, 'Effects of a wheat germ-enriched diet on skeletal muscle regeneration', Italian Journal of Food Science, vol. 15, no. 3, pp. 417-425.
Rizzi C, Chignola R, Zoccatelli G, Donà M, Peruffo ADB, Carraro U et al. Effects of a wheat germ-enriched diet on skeletal muscle regeneration. Italian Journal of Food Science. 2003;15(3):417-425.
Rizzi, C. ; Chignola, R. ; Zoccatelli, G. ; Donà, M. ; Peruffo, A. D B ; Carraro, U. ; Rossini, K. / Effects of a wheat germ-enriched diet on skeletal muscle regeneration. In: Italian Journal of Food Science. 2003 ; Vol. 15, No. 3. pp. 417-425.
@article{46c9501c8107419aa0f47982c7177300,
title = "Effects of a wheat germ-enriched diet on skeletal muscle regeneration",
abstract = "One of the common ingredients used in dietary supplements is wheat germ and its derivatives. In this study the effect of a wheat germ-enriched diet (WGED) on tissue repair was investigated in a model of skeletal muscle damage induced by the anesthetic bupivacaine. Rats were fed normal feedstuff or a WGED; injections of bupivacaine caused skeletal muscle necrosis followed by tissue regeneration. Morphometric analyses were performed on the muscles in order to quantify cell size and nuclei migration toward the cell periphery because these are indices of muscle regeneration. Statistical analysis shows that myoblast maturation, determined by nuclei migration to a peripheral position, was significantly delayed in rats fed wged compared to rats fed the control diet. No statistically significant differences were observed in the myocellular areas. This study provides evidence that dietary wheat germ can interfere with muscle regeneration.",
keywords = "Lectins, Muscle regeneration, Myofibers, Wheat germ",
author = "C. Rizzi and R. Chignola and G. Zoccatelli and M. Don{\`a} and Peruffo, {A. D B} and U. Carraro and K. Rossini",
year = "2003",
language = "English",
volume = "15",
pages = "417--425",
journal = "Italian Journal of Food Science",
issn = "1120-1770",
publisher = "Chiriotti Editori",
number = "3",

}

TY - JOUR

T1 - Effects of a wheat germ-enriched diet on skeletal muscle regeneration

AU - Rizzi, C.

AU - Chignola, R.

AU - Zoccatelli, G.

AU - Donà, M.

AU - Peruffo, A. D B

AU - Carraro, U.

AU - Rossini, K.

PY - 2003

Y1 - 2003

N2 - One of the common ingredients used in dietary supplements is wheat germ and its derivatives. In this study the effect of a wheat germ-enriched diet (WGED) on tissue repair was investigated in a model of skeletal muscle damage induced by the anesthetic bupivacaine. Rats were fed normal feedstuff or a WGED; injections of bupivacaine caused skeletal muscle necrosis followed by tissue regeneration. Morphometric analyses were performed on the muscles in order to quantify cell size and nuclei migration toward the cell periphery because these are indices of muscle regeneration. Statistical analysis shows that myoblast maturation, determined by nuclei migration to a peripheral position, was significantly delayed in rats fed wged compared to rats fed the control diet. No statistically significant differences were observed in the myocellular areas. This study provides evidence that dietary wheat germ can interfere with muscle regeneration.

AB - One of the common ingredients used in dietary supplements is wheat germ and its derivatives. In this study the effect of a wheat germ-enriched diet (WGED) on tissue repair was investigated in a model of skeletal muscle damage induced by the anesthetic bupivacaine. Rats were fed normal feedstuff or a WGED; injections of bupivacaine caused skeletal muscle necrosis followed by tissue regeneration. Morphometric analyses were performed on the muscles in order to quantify cell size and nuclei migration toward the cell periphery because these are indices of muscle regeneration. Statistical analysis shows that myoblast maturation, determined by nuclei migration to a peripheral position, was significantly delayed in rats fed wged compared to rats fed the control diet. No statistically significant differences were observed in the myocellular areas. This study provides evidence that dietary wheat germ can interfere with muscle regeneration.

KW - Lectins

KW - Muscle regeneration

KW - Myofibers

KW - Wheat germ

UR - http://www.scopus.com/inward/record.url?scp=0346270771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346270771&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0346270771

VL - 15

SP - 417

EP - 425

JO - Italian Journal of Food Science

JF - Italian Journal of Food Science

SN - 1120-1770

IS - 3

ER -