Effects of a yeast-based dietary supplementation on premenstrual syndrome. A double-blind placebo-controlled study

Fabio Facchinetti, Rossella E. Nappi, Maria Grazia Sances, Isabella Neri, Giuseppe Grandinetti, Andrea Genazzani

Research output: Contribution to journalArticlepeer-review

Abstract

A dietary approach has proven to be effective in alleviating symptoms of premenstrual syndrome. In our previous studies, magnesium improved premenstrual irritability and mood scoings. In this double-blind, placebo-controlled study, we evaluated the effects of a new dietetic preparation (Sillix Donna®, Giuliani) in 40 patients affected by mild to moderate premenstrual syndrome. Premenstrual symptoms were scored in both follicular and luteal phases, at baseline, at 2nd, 4th and 6th month of treatment by using the Menstrual Distress Questionnaire (MDQ). Twenty patients were randomised to receive the active preparation and 20 placebo. MDQ scores at baseline were similar in the two groups. Five patients of the placebo group dropped out because of treatment failure. No side effects were observed. Both treatments reduced symptoms already in the 2nd month, but the active preparation was more effective at all time controls (p <0.05); at the 6th month it significantly reduced premenstrual MDQ scores to 18% of baseline values, placebo only to 73%. These data demonstrate that Sillix Donna is effective in reducing premenstrual distress.

Original languageEnglish
Pages (from-to)120-124
Number of pages5
JournalGynecologic and Obstetric Investigation
Volume43
Issue number2
Publication statusPublished - Feb 1997

Keywords

  • Magnesium
  • Moos Menstrual Distress Questionnaire score
  • Premenstrual distress
  • Premenstrual syndrome
  • Pyridoxine
  • Yeast

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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