Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients

Francesco Cacciatore, Giuseppe Bruzzese, Dino Franco Vitale, Antonio Liguori, Filomena De Nigris, Carmela Fiorito, Teresa Infante, Francesco Donatelli, Pellegrino Biagio Minucci, Louis Joseph Ignarro, Claudio Napoli

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Purpose The pathogenic role of angiotensin-converting enzyme (ACE) inhibition in hypertensive patients regarding endothelial progenitor-cell (EPC) function is still poorly understood. The aim of the study was to evaluate EPC number, function, and relationship to carotid intima media thickness (IMT) progression. Methods We studied 36 newly diagnosed mildly hypertensive patients free of cardiovascular disease and related risk factors without prior or concurrent therapy with ACE inhibitors. Patients were randomized to receive enalapril 20 mg/day (n=18) or zofenopril 30 mg/day (n=18). EPC number and migrating capacity, plasma nitrite and nitrate (NOx), and isoprostane concentrations were evaluated. Carotid IMT was determined by ultrasonography at baseline and after 1 and 5 years of follow-up. Results EPC number increased during the follow-up, with no statistical differences between treatment groups. There was an inverse correlation between circulating EPCs and IMTincrease over time. Plasma NOx decreased during the study without evident differences between treatment groups. Isoprostanes decreased more markedly in zofenopril-treated patients. Multiple linear regression model demonstrated that carotid IMT was significantly inversely correlated with EPC but not with migratory cells after adjusting for confounders. Conclusions The study demonstrated that EPC levels increased during the follow-up in both groups of newly diagnosed hypertensive patients treated with ACE inhibitors. These drugs prevented progression of vascular damage, with an inverse correlation between circulating EPC levels and IMT values.

Original languageEnglish
Pages (from-to)877-883
Number of pages7
JournalEuropean Journal of Clinical Pharmacology
Volume67
Issue number9
DOIs
Publication statusPublished - Sep 2011

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Peptidyl-Dipeptidase A
Blood Vessels
Oxidative Stress
zofenopril
Carotid Intima-Media Thickness
Isoprostanes
Cell Count
Angiotensin-Converting Enzyme Inhibitors
Linear Models
Enalapril
Nitrites
Endothelial Progenitor Cells
Nitrates
Ultrasonography
Cardiovascular Diseases
Therapeutics
Pharmaceutical Preparations

Keywords

  • ACE inhibitors
  • EPC
  • Hypertension
  • Vascular damage

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients. / Cacciatore, Francesco; Bruzzese, Giuseppe; Vitale, Dino Franco; Liguori, Antonio; Nigris, Filomena De; Fiorito, Carmela; Infante, Teresa; Donatelli, Francesco; Minucci, Pellegrino Biagio; Ignarro, Louis Joseph; Napoli, Claudio.

In: European Journal of Clinical Pharmacology, Vol. 67, No. 9, 09.2011, p. 877-883.

Research output: Contribution to journalArticle

Cacciatore, Francesco ; Bruzzese, Giuseppe ; Vitale, Dino Franco ; Liguori, Antonio ; Nigris, Filomena De ; Fiorito, Carmela ; Infante, Teresa ; Donatelli, Francesco ; Minucci, Pellegrino Biagio ; Ignarro, Louis Joseph ; Napoli, Claudio. / Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients. In: European Journal of Clinical Pharmacology. 2011 ; Vol. 67, No. 9. pp. 877-883.
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