Effects of aclidinium on determinants of COPD severity: Symptoms and quality of life

M. Contoli, Paolo Solidoro, F. Marco, N. Scichilone, A. Corsico, F. Braido, P. Santus

Research output: Contribution to journalReview article

Abstract

The pathophysiology of chronic obstructive pulmonary disease (COPD) includes persistent airflow limitation, altered gas exchange, and enhanced chronic inflammatory response. According to disease severity in individual patients, exacerbations and comorbidities frequently occur. The overall nocturnal and daily symptoms have a strong impact on patient quality of life and clinical outcomes. Bronchodilators, by targeting two important aspects of COPD pathophysiology, ie, bronchoconstriction and lung hyperinflation, are the mainstay of therapy for COPD. Aclidinium bromide in particular is an anticholinergic molecule, approved for maintenance bronchodilator treatment of stable COPD, that combines high antimuscarinic activity with strong kinetic selectivity for the M3 receptor subtype. Moreover, the elevated plasma clearance of aclidinium has been related to low systemic bioavailability and low incidence of anticholinergic adverse events, whereas the reduced residence time at M2 receptors provides good cardiovascular safety. Altogether, these characteristics result in a high safety and tolerability profile. This review aims to reappraise the contribution of symptoms and of the level of quality of life determinants on COPD severity and to evaluate how therapeutic strategies with aclidinium may positively impact on these specific determinants of disease severity. © 2016 Contoli et al.
Original languageEnglish
Pages (from-to)3043-3050
Number of pages8
JournalInternational Journal of COPD
Volume11
Issue number1
DOIs
Publication statusPublished - 2016

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Keywords

  • Aclidinium
  • COPD
  • Daily symptoms
  • LAMA
  • Quality of life

Cite this

Contoli, M., Solidoro, P., Marco, F., Scichilone, N., Corsico, A., Braido, F., & Santus, P. (2016). Effects of aclidinium on determinants of COPD severity: Symptoms and quality of life. International Journal of COPD, 11(1), 3043-3050. https://doi.org/10.2147/COPD.S122433