Effects of acute benzodiazepine administration on growth hormone, prolactin and cortisol release after moderate insulin-induced hypoglycemia in normal women

F. Ambrosi, S. Ricci, R. Quartesan, P. Moretti, G. Pelicci, C. Pagliacci, I. Nicoletti

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Benzodiazepines are known to affect pituitary hormone release, and it has recently been hypothesized that the adenohypophysial hormone response to stress may be modified by previous benzodiazepine treatment. We investigated, therefore, whether a single dose of triazolam, a short-acting benzodiazepine, and flurazepam, a long-acting one, could influence the response of prolactin (PRL), growth hormone (GH) and cortisol to a mild hypoglycemic stress in young healthy volunteers. Neither triazolam nor flurazepam pretreatment resulted in a significant effect on the pituitary response to hypoglycemic stimulus. The GH, PRL and cortisol peaks after both benzodiazepines were similar to those observed after placebo. Our results seem to exclude, therefore, any relevant effect of acute benzodiazepine administration on the neuroendocrine response to mild stress.

Original languageEnglish
Pages (from-to)187-189
Number of pages3
JournalPsychopharmacology
Volume88
Issue number2
DOIs
Publication statusPublished - Jun 1986

Fingerprint

Benzodiazepines
Hypoglycemia
Prolactin
Growth Hormone
Hydrocortisone
Insulin
Flurazepam
Triazolam
Hypoglycemic Agents
Anterior Pituitary Hormones
Pituitary Hormones
Healthy Volunteers
Placebos
Therapeutics

Keywords

  • Benzodiazepines
  • Pituitary hormones
  • Stress

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of acute benzodiazepine administration on growth hormone, prolactin and cortisol release after moderate insulin-induced hypoglycemia in normal women. / Ambrosi, F.; Ricci, S.; Quartesan, R.; Moretti, P.; Pelicci, G.; Pagliacci, C.; Nicoletti, I.

In: Psychopharmacology, Vol. 88, No. 2, 06.1986, p. 187-189.

Research output: Contribution to journalArticle

Ambrosi, F. ; Ricci, S. ; Quartesan, R. ; Moretti, P. ; Pelicci, G. ; Pagliacci, C. ; Nicoletti, I. / Effects of acute benzodiazepine administration on growth hormone, prolactin and cortisol release after moderate insulin-induced hypoglycemia in normal women. In: Psychopharmacology. 1986 ; Vol. 88, No. 2. pp. 187-189.
@article{bd7b0980adca4302a27629dd576ff327,
title = "Effects of acute benzodiazepine administration on growth hormone, prolactin and cortisol release after moderate insulin-induced hypoglycemia in normal women",
abstract = "Benzodiazepines are known to affect pituitary hormone release, and it has recently been hypothesized that the adenohypophysial hormone response to stress may be modified by previous benzodiazepine treatment. We investigated, therefore, whether a single dose of triazolam, a short-acting benzodiazepine, and flurazepam, a long-acting one, could influence the response of prolactin (PRL), growth hormone (GH) and cortisol to a mild hypoglycemic stress in young healthy volunteers. Neither triazolam nor flurazepam pretreatment resulted in a significant effect on the pituitary response to hypoglycemic stimulus. The GH, PRL and cortisol peaks after both benzodiazepines were similar to those observed after placebo. Our results seem to exclude, therefore, any relevant effect of acute benzodiazepine administration on the neuroendocrine response to mild stress.",
keywords = "Benzodiazepines, Pituitary hormones, Stress",
author = "F. Ambrosi and S. Ricci and R. Quartesan and P. Moretti and G. Pelicci and C. Pagliacci and I. Nicoletti",
year = "1986",
month = "6",
doi = "10.1007/BF00652238",
language = "English",
volume = "88",
pages = "187--189",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Effects of acute benzodiazepine administration on growth hormone, prolactin and cortisol release after moderate insulin-induced hypoglycemia in normal women

AU - Ambrosi, F.

AU - Ricci, S.

AU - Quartesan, R.

AU - Moretti, P.

AU - Pelicci, G.

AU - Pagliacci, C.

AU - Nicoletti, I.

PY - 1986/6

Y1 - 1986/6

N2 - Benzodiazepines are known to affect pituitary hormone release, and it has recently been hypothesized that the adenohypophysial hormone response to stress may be modified by previous benzodiazepine treatment. We investigated, therefore, whether a single dose of triazolam, a short-acting benzodiazepine, and flurazepam, a long-acting one, could influence the response of prolactin (PRL), growth hormone (GH) and cortisol to a mild hypoglycemic stress in young healthy volunteers. Neither triazolam nor flurazepam pretreatment resulted in a significant effect on the pituitary response to hypoglycemic stimulus. The GH, PRL and cortisol peaks after both benzodiazepines were similar to those observed after placebo. Our results seem to exclude, therefore, any relevant effect of acute benzodiazepine administration on the neuroendocrine response to mild stress.

AB - Benzodiazepines are known to affect pituitary hormone release, and it has recently been hypothesized that the adenohypophysial hormone response to stress may be modified by previous benzodiazepine treatment. We investigated, therefore, whether a single dose of triazolam, a short-acting benzodiazepine, and flurazepam, a long-acting one, could influence the response of prolactin (PRL), growth hormone (GH) and cortisol to a mild hypoglycemic stress in young healthy volunteers. Neither triazolam nor flurazepam pretreatment resulted in a significant effect on the pituitary response to hypoglycemic stimulus. The GH, PRL and cortisol peaks after both benzodiazepines were similar to those observed after placebo. Our results seem to exclude, therefore, any relevant effect of acute benzodiazepine administration on the neuroendocrine response to mild stress.

KW - Benzodiazepines

KW - Pituitary hormones

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=0022641099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022641099&partnerID=8YFLogxK

U2 - 10.1007/BF00652238

DO - 10.1007/BF00652238

M3 - Article

C2 - 3081931

AN - SCOPUS:0022641099

VL - 88

SP - 187

EP - 189

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 2

ER -