Effects of acute benzodiazepine administration on growth hormone, prolactin and cortisol release after moderate insulin-induced hypoglycemia in normal women

F. Ambrosi, S. Ricci, R. Quartesan, P. Moretti, G. Pelicci, C. Pagliacci, I. Nicoletti

Research output: Contribution to journalArticle

Abstract

Benzodiazepines are known to affect pituitary hormone release, and it has recently been hypothesized that the adenohypophysial hormone response to stress may be modified by previous benzodiazepine treatment. We investigated, therefore, whether a single dose of triazolam, a short-acting benzodiazepine, and flurazepam, a long-acting one, could influence the response of prolactin (PRL), growth hormone (GH) and cortisol to a mild hypoglycemic stress in young healthy volunteers. Neither triazolam nor flurazepam pretreatment resulted in a significant effect on the pituitary response to hypoglycemic stimulus. The GH, PRL and cortisol peaks after both benzodiazepines were similar to those observed after placebo. Our results seem to exclude, therefore, any relevant effect of acute benzodiazepine administration on the neuroendocrine response to mild stress.

Original languageEnglish
Pages (from-to)187-189
Number of pages3
JournalPsychopharmacology
Volume88
Issue number2
DOIs
Publication statusPublished - Jun 1986

Keywords

  • Benzodiazepines
  • Pituitary hormones
  • Stress

ASJC Scopus subject areas

  • Pharmacology

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