In the attempt to elucidate the complex differential interaction of adriamycin (AM) and daunomycin (DM) with immune reactivity, the effects of these agents on spleen cell subpopulations were investigated in normal and tumor-allografted drugpretreated mice. In terms of total organ cellularity, DM induced a faster and longer lasting cell-depletion than AM, although the nadir values were similar for both drugs. The percentages of theta positive and EA-rosette forming cells (EA-RFCs) were not modified by the two drugs in normal animals, whereas the increase in percent EA-RFCs observed in control tumor allografted mice was partially inhibited by both drugs. Macrophages were relatively spared by these agents as evidenced by an increase in their percent value.
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