Effects of age-related loss of P/Q-type calcium channels in a mice model of peripheral nerve injury

Sara Marinelli, Cecilia Eleuteri, Valentina Vacca, Georgios Strimpakos, Elisabetta Mattei, Cinzia Severini, Flaminia Pavone, Siro Luvisetto

Research output: Contribution to journalArticle

Abstract

We analyzed the role of P/Q-type calcium channels in sciatic nerve regeneration after lesion induced by chronic constriction injury (CCI) in heterozygous null mutant mice lacking the CaV2.1α1 subunit of these channels (Cacna1a+/-). Compared with wild type, Cacna1a+/- mice showed an initial reduction of the CCI-induced allodynia, indicating a reduced pain perception, but they also evidenced a lack of recovery over time, with atrophy of the injured hindpaw still present 3months after CCI when wild-type mice fully recovered. In parallel, Cacna1a+/- mice exhibited an early onset of age-dependent loss of P/Q-type channels, which can be responsible for the lack of functional recovery. Moreover, Cacna1a+/- mice showed an early age-dependent reduction of muscular strength, as well as of Schwann cells proliferation and sciatic nerve remyelination. This study demonstrates the important role played by P/Q-type channels in recovery from nerve injury and has important implications for the knowledge of age-related processes.

Original languageEnglish
Pages (from-to)352-364
Number of pages13
JournalNeurobiology of Aging
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Allodynia
  • Cacna1a
  • Muscle
  • Nerve regeneration
  • P/Q-type channels
  • Schwann cells

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Effects of age-related loss of P/Q-type calcium channels in a mice model of peripheral nerve injury'. Together they form a unique fingerprint.

  • Cite this

    Marinelli, S., Eleuteri, C., Vacca, V., Strimpakos, G., Mattei, E., Severini, C., Pavone, F., & Luvisetto, S. (2015). Effects of age-related loss of P/Q-type calcium channels in a mice model of peripheral nerve injury. Neurobiology of Aging, 36(1), 352-364. https://doi.org/10.1016/j.neurobiolaging.2014.07.025