Effects of age-related loss of P/Q-type calcium channels in a mice model of peripheral nerve injury

Sara Marinelli, Cecilia Eleuteri, Valentina Vacca, Georgios Strimpakos, Elisabetta Mattei, Cinzia Severini, Flaminia Pavone, Siro Luvisetto

Research output: Contribution to journalArticlepeer-review


We analyzed the role of P/Q-type calcium channels in sciatic nerve regeneration after lesion induced by chronic constriction injury (CCI) in heterozygous null mutant mice lacking the CaV2.1α1 subunit of these channels (Cacna1a+/-). Compared with wild type, Cacna1a+/- mice showed an initial reduction of the CCI-induced allodynia, indicating a reduced pain perception, but they also evidenced a lack of recovery over time, with atrophy of the injured hindpaw still present 3months after CCI when wild-type mice fully recovered. In parallel, Cacna1a+/- mice exhibited an early onset of age-dependent loss of P/Q-type channels, which can be responsible for the lack of functional recovery. Moreover, Cacna1a+/- mice showed an early age-dependent reduction of muscular strength, as well as of Schwann cells proliferation and sciatic nerve remyelination. This study demonstrates the important role played by P/Q-type channels in recovery from nerve injury and has important implications for the knowledge of age-related processes.

Original languageEnglish
Pages (from-to)352-364
Number of pages13
JournalNeurobiology of Aging
Issue number1
Publication statusPublished - Jan 1 2015


  • Allodynia
  • Cacna1a
  • Muscle
  • Nerve regeneration
  • P/Q-type channels
  • Schwann cells

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology
  • Medicine(all)


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