Effects of aging and beta-adrenergic-blockade on standing-induced QT/QS2 changes

L. De Caprio, M. Papa, D. Acanfora, S. Cuomo, C. Vigorito, A. M. Cicatiello, V. Canonico, F. Gallucci, F. Rengo

Research output: Contribution to journalArticle

Abstract

In order to evaluate whether the changes in the electrical systole/electromechanical systole ratio (QT/QS2) may reflect the effects of beta-adrenergic stimulation on the heart, we studied the variations of this ratio induced by active standing. We studied 45 healthy volunteers aged 15 to 82 years, subdivided into three groups; Group 1 (mean age 22 ± 4 years), Group 2 (mean age 44 ± 6 years), and Group 3 (mean age 74 ± 6 years). Fifteen subjects repeated the test after propranolol administration (0.1 mg/kg iv). Resting QT/QS2 ratio increased slightly, but not significantly, with age. Upright position significantly increased QT/QS2 ratio in all groups. Changes in heart rate (r = -.43), electromechanical systole (r = .55) and QT/QS2 ratio (r = -.66) were significantly correlated with age. Propranolol prevented the increase in QT/QS2 ratio induced by active standing. Therefore, QT/QS2 changes induced by standing are correlated with age and are inhibited or reduced by beta-blockade. QT/QS2 changes can be used to monitor adrenergic activity, even if their value is limited by the overlapping responses of the individual cases.

Original languageEnglish
JournalJournals of Gerontology
Volume44
Issue number1
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Ageing

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    De Caprio, L., Papa, M., Acanfora, D., Cuomo, S., Vigorito, C., Cicatiello, A. M., Canonico, V., Gallucci, F., & Rengo, F. (1989). Effects of aging and beta-adrenergic-blockade on standing-induced QT/QS2 changes. Journals of Gerontology, 44(1).