Abstract
The effects of once-daily amlodipine 10 mg or enalapril 20 mg on urinary albumin excretion (UAE) were evaluated over 12 months, in a randomised trial of 50 hypertensive patients with type II (non-insulin-dependent) diabetes mellitus and microalbuminuria. Both drugs significantly reduced systolic and diastolic blood pressure without affecting heart rate or glucose homeostasis. UAE was significantly reduced after 3 months of treatment with enalapril, and 6 months of therapy with amlodipine. The percentage reduction in UAE significantly correlated with the decrement in systolic blood pressure and duration of hypertension in both treatment groups. Creatinine clearance was unaffected by enalapril, but was significantly increased by amlodipine. Long term treatment with either amlodipine or enalapril was therefore effective in reducing UAE in hypertensive patients with type II diabetes and microalbuminuria.
| Original language | English |
|---|---|
| Pages (from-to) | 42-49 |
| Number of pages | 8 |
| Journal | Clinical Drug Investigation |
| Volume | 13 |
| Issue number | SUPPL. 1 |
| Publication status | Published - 1997 |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
Cite this
Effects of amlodipine vs enalapril on microalbuminuria in hypertensive patients with type II diabetes. / Fogari, R.; Zoppi, A.; Malamani, G. D.; Lusardi, P.; Destro, M.; Corradi, L.
In: Clinical Drug Investigation, Vol. 13, No. SUPPL. 1, 1997, p. 42-49.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effects of amlodipine vs enalapril on microalbuminuria in hypertensive patients with type II diabetes
AU - Fogari, R.
AU - Zoppi, A.
AU - Malamani, G. D.
AU - Lusardi, P.
AU - Destro, M.
AU - Corradi, L.
PY - 1997
Y1 - 1997
N2 - The effects of once-daily amlodipine 10 mg or enalapril 20 mg on urinary albumin excretion (UAE) were evaluated over 12 months, in a randomised trial of 50 hypertensive patients with type II (non-insulin-dependent) diabetes mellitus and microalbuminuria. Both drugs significantly reduced systolic and diastolic blood pressure without affecting heart rate or glucose homeostasis. UAE was significantly reduced after 3 months of treatment with enalapril, and 6 months of therapy with amlodipine. The percentage reduction in UAE significantly correlated with the decrement in systolic blood pressure and duration of hypertension in both treatment groups. Creatinine clearance was unaffected by enalapril, but was significantly increased by amlodipine. Long term treatment with either amlodipine or enalapril was therefore effective in reducing UAE in hypertensive patients with type II diabetes and microalbuminuria.
AB - The effects of once-daily amlodipine 10 mg or enalapril 20 mg on urinary albumin excretion (UAE) were evaluated over 12 months, in a randomised trial of 50 hypertensive patients with type II (non-insulin-dependent) diabetes mellitus and microalbuminuria. Both drugs significantly reduced systolic and diastolic blood pressure without affecting heart rate or glucose homeostasis. UAE was significantly reduced after 3 months of treatment with enalapril, and 6 months of therapy with amlodipine. The percentage reduction in UAE significantly correlated with the decrement in systolic blood pressure and duration of hypertension in both treatment groups. Creatinine clearance was unaffected by enalapril, but was significantly increased by amlodipine. Long term treatment with either amlodipine or enalapril was therefore effective in reducing UAE in hypertensive patients with type II diabetes and microalbuminuria.
UR - http://www.scopus.com/inward/record.url?scp=0030808110&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030808110&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0030808110
VL - 13
SP - 42
EP - 49
JO - Clinical Drug Investigation
JF - Clinical Drug Investigation
SN - 1173-2563
IS - SUPPL. 1
ER -