Effects of amylin on human osteoblast-like cells

I. Villa, A. Rubinacci, F. Ravasi, A. F. Ferrara, F. Guidobono

Research output: Contribution to journalArticlepeer-review


Amylin has been reported to have bone-conserving effects. In the present study we evaluated the possible activity of the peptide on human osteoblast-like (hOB) cells in primary culture. Amylin between 10 -9 and 10 -6 M, dose-dependently stimulated cell proliferation with a maximal effect (200%) at 10 -6 M. In addition, amylin increased osteocalcin production when hOB cells were exposed to 1,25(OH) 2D 3 (10 -8 M) but there was a nonsignificant upward trend on alkaline phosphatase activity. The present results suggest that amylin could be included among the group of peptides endowed with osteogenic activity.

Original languageEnglish
Pages (from-to)537-540
Number of pages4
Issue number4
Publication statusPublished - 1997


  • Alkaline phosphatase
  • Amylin
  • Osteoblast-like cells
  • Osteocalcin
  • Proliferation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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