Effects of an estrogen-free, desogestrel-containing oral contraceptive in women with migraine with aura: A prospective diary-based pilot study

Rossella E. Nappi, Grazia Sances, Gianni Allais, Erica Terreno, Chiara Benedetto, Valentina Vaccaro, Franco Polatti, Fabio Facchinetti

Research output: Contribution to journalArticle

Abstract

Background: Migraine with aura (MA) is a contraindication to the use of combined oral contraceptives (COCs) because of the increased risk of ischemic stroke. Progestogen-only contraceptive pill (POP) is a safe alternative to COCs and it is preferable in women with cerebrovascular diseases or risk factors for stroke. Study Design: Prospective diary-based pilot study. Thirty women with MA (n=15 who have never used COCs and n=15 who had previously used COCs were diagnosed according to the International Headache Society criteria. The observational period lasted 9 months during which women filled in a diary with the clinical characteristics of headache attacks. After a 3-month run-in period, each subject received an estrogen-free desogestrel (DSG) (75 mcg/day)-containing OC (Cerazette®; Schering-Plough, formerly NV Organon, Oss, The Netherlands). Follow-up evaluations were planned at the end of the third and sixth month of treatment. Results: The number (mean±S.D.) of migraine attacks was significantly reduced both in previous COCs users (from 3.9±1.0 to 2.9±0.8; p

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalContraception
Volume83
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Desogestrel
  • Estrogen-free contraception
  • Headache diary
  • Migraine with aura
  • Progestogen-only pill (POP)

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Effects of an estrogen-free, desogestrel-containing oral contraceptive in women with migraine with aura: A prospective diary-based pilot study'. Together they form a unique fingerprint.

  • Cite this