Abstract
Objective: To determine the effect of the androgen supplementation of hormone replacement therapy (HRT) on the vascular reactivity of cerebral arteries. Design: Open randomized study. Setting: Healthy volunteers in an academic research environment. Patient(s): Forty postmenopausal women who were treated with sequential HRT (transdermal E2 50 μg/d + medroxyprogesterone acetate 10 mg/d for 12 days every other month) for ≥1 year and ≤5 years. Intervention(s): Testosterone undecanoate (40 mg/d, p.o.) was randomly administered to 20 patients during ongoing HRT; the other 20 served as controls. Doppler evaluations of the internal carotid and middle cerebral arteries were performed together with lipid levels assessments. A visual analogue scale (VAS) was used to evaluate various parameters relating to sexual life and well-being. Main Outcome Measure(s): Pulsatility index (PI) of the arteries, VAS assessment of psychophysical well-being. Result(s): The administration of testosterone undecanoate during HRT induced an increase in the PI of the middle cerebral artery and a reduction of high-density lipoprotein cholesterol. Sexual desire and satisfaction were greatly improved. Conclusion(s): In postmenopausal women, androgen supplementation during HRT can partially counteract the beneficial effects of estrogens on cerebral vascular reactivity and lipid profiles, but sexual desire and satisfaction are greatly improved.
| Original language | English |
|---|---|
| Pages (from-to) | 235-240 |
| Number of pages | 6 |
| Journal | Fertility and Sterility |
| Volume | 76 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2001 |
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Keywords
- Androgen
- HRT
- Lipids
- Menopause
- Sexual behavior
- Vascular reactivity
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Effects of androgen supplementation of hormone replacement therapy on the vascular reactivity of cerebral arteries. / Penotti, Maurio; Sironi, Laura; Cannata, Letizia; Viganò, Paola; Casini, Andrea; Gabrielli, Livio; Vignali, Mario.
In: Fertility and Sterility, Vol. 76, No. 2, 2001, p. 235-240.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of androgen supplementation of hormone replacement therapy on the vascular reactivity of cerebral arteries
AU - Penotti, Maurio
AU - Sironi, Laura
AU - Cannata, Letizia
AU - Viganò, Paola
AU - Casini, Andrea
AU - Gabrielli, Livio
AU - Vignali, Mario
PY - 2001
Y1 - 2001
N2 - Objective: To determine the effect of the androgen supplementation of hormone replacement therapy (HRT) on the vascular reactivity of cerebral arteries. Design: Open randomized study. Setting: Healthy volunteers in an academic research environment. Patient(s): Forty postmenopausal women who were treated with sequential HRT (transdermal E2 50 μg/d + medroxyprogesterone acetate 10 mg/d for 12 days every other month) for ≥1 year and ≤5 years. Intervention(s): Testosterone undecanoate (40 mg/d, p.o.) was randomly administered to 20 patients during ongoing HRT; the other 20 served as controls. Doppler evaluations of the internal carotid and middle cerebral arteries were performed together with lipid levels assessments. A visual analogue scale (VAS) was used to evaluate various parameters relating to sexual life and well-being. Main Outcome Measure(s): Pulsatility index (PI) of the arteries, VAS assessment of psychophysical well-being. Result(s): The administration of testosterone undecanoate during HRT induced an increase in the PI of the middle cerebral artery and a reduction of high-density lipoprotein cholesterol. Sexual desire and satisfaction were greatly improved. Conclusion(s): In postmenopausal women, androgen supplementation during HRT can partially counteract the beneficial effects of estrogens on cerebral vascular reactivity and lipid profiles, but sexual desire and satisfaction are greatly improved.
AB - Objective: To determine the effect of the androgen supplementation of hormone replacement therapy (HRT) on the vascular reactivity of cerebral arteries. Design: Open randomized study. Setting: Healthy volunteers in an academic research environment. Patient(s): Forty postmenopausal women who were treated with sequential HRT (transdermal E2 50 μg/d + medroxyprogesterone acetate 10 mg/d for 12 days every other month) for ≥1 year and ≤5 years. Intervention(s): Testosterone undecanoate (40 mg/d, p.o.) was randomly administered to 20 patients during ongoing HRT; the other 20 served as controls. Doppler evaluations of the internal carotid and middle cerebral arteries were performed together with lipid levels assessments. A visual analogue scale (VAS) was used to evaluate various parameters relating to sexual life and well-being. Main Outcome Measure(s): Pulsatility index (PI) of the arteries, VAS assessment of psychophysical well-being. Result(s): The administration of testosterone undecanoate during HRT induced an increase in the PI of the middle cerebral artery and a reduction of high-density lipoprotein cholesterol. Sexual desire and satisfaction were greatly improved. Conclusion(s): In postmenopausal women, androgen supplementation during HRT can partially counteract the beneficial effects of estrogens on cerebral vascular reactivity and lipid profiles, but sexual desire and satisfaction are greatly improved.
KW - Androgen
KW - HRT
KW - Lipids
KW - Menopause
KW - Sexual behavior
KW - Vascular reactivity
UR - http://www.scopus.com/inward/record.url?scp=0034899879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034899879&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(01)01923-9
DO - 10.1016/S0015-0282(01)01923-9
M3 - Article
VL - 76
SP - 235
EP - 240
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 2
ER -