Effects of angiotensin-converting enzyme inhibition on left ventricular geometric patterns in patients with essential hypertension

Stefano De Castro, Francesco Pelliccia, Domenico Cartoni, Stefania Funaro, Guido Melillo, Sergio Beni, Giuseppina Magni, Giorgio Migliau, Francesco Fedele

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Abstract

Although angiotensin converting enzyme inhibitors have been shown to affect left ventricular (LV) remodeling favorably in several conditions, it remains unclear whether they can influence LV geometric pattern in hypertension. To address this issue, 122 patients (71 men and 51 women; mean age = 51 ± 10 years) with mild to moderate hypertension were studied prospectively. All underwent clinical evaluation and Doppler echocardiography at entry and more than 2 years of quinapril therapy (10-40 mg/day). According to either LV mass (normal if 2 for men or 2 for women) or the ratio of LV posterior wall thickness to diastolic diameter (RWT; normal if

Original languageEnglish
Pages (from-to)1141-1148
Number of pages8
JournalJournal of Clinical Pharmacology
Volume36
Issue number12
Publication statusPublished - 1996

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ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

De Castro, S., Pelliccia, F., Cartoni, D., Funaro, S., Melillo, G., Beni, S., Magni, G., Migliau, G., & Fedele, F. (1996). Effects of angiotensin-converting enzyme inhibition on left ventricular geometric patterns in patients with essential hypertension. Journal of Clinical Pharmacology, 36(12), 1141-1148.