Effects of antibiotics on the bactericidal activity of human serum

A. Fietta, P. Mangiarotti, G. G. Grassi

Research output: Contribution to journalArticle

Abstract

The interaction between several antibodies and either normal human serum or EGTA-chelated Mg-treated serum has been tested. Synergism has been observed with rifampicin, tetracycline and doxycycline, but not with minocycline, aminoglycosides (kanamycin, tobramycin, gentamicin, sisomicin and amikacin), chloramphenicol, fosfomycin and erythromycin. It has been demonstrated that Escherichia coli K12 stains bearing plasmids, conferring resistance to tetracycline, were killed in the presence of serum. Evidence has been presented that this synergistic action depends on complement and can be abolished by serum treatment with ethyleneglycol-tetraacetic acid.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalJournal of Antimicrobial Chemotherapy
Volume9
Issue number2
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Microbiology
  • Pharmacology

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    Fietta, A., Mangiarotti, P., & Grassi, G. G. (1982). Effects of antibiotics on the bactericidal activity of human serum. Journal of Antimicrobial Chemotherapy, 9(2), 141-148.