Effects of antibiotics on the bactericidal activity of human serum

A. Fietta, P. Mangiarotti, G. G. Grassi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The interaction between several antibodies and either normal human serum or EGTA-chelated Mg-treated serum has been tested. Synergism has been observed with rifampicin, tetracycline and doxycycline, but not with minocycline, aminoglycosides (kanamycin, tobramycin, gentamicin, sisomicin and amikacin), chloramphenicol, fosfomycin and erythromycin. It has been demonstrated that Escherichia coli K12 stains bearing plasmids, conferring resistance to tetracycline, were killed in the presence of serum. Evidence has been presented that this synergistic action depends on complement and can be abolished by serum treatment with ethyleneglycol-tetraacetic acid.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalJournal of Antimicrobial Chemotherapy
Volume9
Issue number2
Publication statusPublished - 1982

Fingerprint

Human Activities
Anti-Bacterial Agents
Serum
Sisomicin
Fosfomycin
Tetracycline Resistance
Escherichia coli K12
Minocycline
Tobramycin
Kanamycin
Amikacin
Doxycycline
Egtazic Acid
Aminoglycosides
Chloramphenicol
Erythromycin
Rifampin
Gentamicins
Tetracycline
Plasmids

ASJC Scopus subject areas

  • Microbiology
  • Pharmacology

Cite this

Effects of antibiotics on the bactericidal activity of human serum. / Fietta, A.; Mangiarotti, P.; Grassi, G. G.

In: Journal of Antimicrobial Chemotherapy, Vol. 9, No. 2, 1982, p. 141-148.

Research output: Contribution to journalArticle

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