Effects of antihypertensive drugs on carotid intima-media thickness

Focus on angiotensin II receptor blockers. A review of randomized, controlled trials

Cesare Cuspidi, Francesca Negri, Valentina Giudici, Anna Capra, Carla Sala

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Carotid intima-media thickness (IMT) and plaques have been shown to have a strong continuous relationship with cardiovascular (CV) morbidity and mortality; therefore, carotid atherosclerosis, as assessed by ultrasonography, can be regarded as a reliable surrogate end-point for therapeutic interventions. In this survey, we report the results of 16 double blind, randomized, controlled studies comparing: 1) antihypertensive drugs versus placebo/no treatment (five trials including 3,215 patients); 2) different active antihypertensive drug regimens (five trials including 4,662 patients); 3) angiotensin-II receptor blockers (ARBs) versus other antihypertensive agents (six trials including 841 patients). Our main findings can be summarized as follows: I) Long-term antihypertensive treatment has a blunting effect on carotid IMT progression, regardless of types of drugs. II) Calcium-channel blockers (CCBs) are more effective than other antihypertensive drugs including diuretics, beta-blockers, and angiotensin converting-enzyme (ACE)-inhibitors in this blunting effect; III) the effect of ARBs compared to other antihypertensive regimens (mostly based on atenolol) on carotid atherosclerosis progression needs to be further elucidated, as a protective effect was demonstrated by some, but not all studies examined. Thus, further studies are needed to clarify the role of ARBs in this therapeutic area.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalIntegrated Blood Pressure Control
Volume2
Publication statusPublished - 2009

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Carotid Intima-Media Thickness
Angiotensin Receptor Antagonists
Antihypertensive Agents
Randomized Controlled Trials
Carotid Artery Diseases
Atenolol
Calcium Channel Blockers
Therapeutics
Angiotensin-Converting Enzyme Inhibitors
Diuretics
Ultrasonography
Biomarkers
Placebos
Morbidity
Mortality
Pharmaceutical Preparations

Keywords

  • Angiotensin II receptor blockers
  • Antihypertensive drugs
  • Carotid atherosclerosis
  • Ultrasonography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Effects of antihypertensive drugs on carotid intima-media thickness : Focus on angiotensin II receptor blockers. A review of randomized, controlled trials. / Cuspidi, Cesare; Negri, Francesca; Giudici, Valentina; Capra, Anna; Sala, Carla.

In: Integrated Blood Pressure Control, Vol. 2, 2009, p. 1-8.

Research output: Contribution to journalArticle

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