Effects of antilipolytic agents on glucose utilization by adipose tissue

Adalgisa Bizzi, Anna M. Codegoni, Aldo Medea, Silvio Garattini

Research output: Contribution to journalArticlepeer-review


There is a biphasic response in the rate of glucose utilization when epididymal adipose tissue from fasted rats pretreated with lipolysis inhibitors, nicotinic acid or 5-carboxy-3-methylpyrazole (5C3MP), is incubated in vitro. Epididymal adipose tissue taken 10 min after administration of both agents, converted more glucose to CO2 and incorporated more glucose into lipids. The reverse was seen when adipose tissues were incubated 1-6 hr after treatment. No changes in sensitivity to insulin or to norepinephrine were observed. Glucose utilization by diaphragm was not changed by the treatment with 5C3MP.

Original languageEnglish
Pages (from-to)763-768
Number of pages6
JournalBiochemical Pharmacology
Issue number6
Publication statusPublished - Mar 15 1973

ASJC Scopus subject areas

  • Pharmacology


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