Effects of apomorphine and sodium di-n-propylacetate on the aggressive behaviour of three strains of mice

Stefano Puglisi Allegra, Gerard Mack, Alberto Oliverio, Paul Mandel

Research output: Contribution to journalArticlepeer-review

Abstract

1. 1. The effects of apomorphine and sodium Di-n-propylacetate (DPA, sodium valproate) on pain-induced aggressive behavior were investigated in three inbred strains of mice: BALB/c, C57B1/6 and DBA/2, which exhibited spontaneously low levels of aggression. 2. 2. Apomorphine elicited aggressive behavior in the three strains, the range of effective doses being different for each strain of mice. 3. 3. Di-n-propylacetate was effective in inhibiting apomorphine elicited aggression but the three strains exhibited a different sensitivity to this drug. 4. 4. The effects of Di-n-propylacetate were not related to pain sensitivity, posture and locomotion. Only C57 strain exhibited a slight postural and locomotor impairment when injected with a higher dose of Di-n-propylacetate. 5. 5. The results are discussed in terms of a genetic inference and of biological differences existing between these three strains.

Original languageEnglish
Pages (from-to)491-502
Number of pages12
JournalProgress in Neuro-Psychopharmacology
Volume3
Issue number5-6
DOIs
Publication statusPublished - 1979

Keywords

  • apomorphine
  • Di-n-propylacetate
  • inbred strains of mice
  • inhibition of aggression
  • pain-induced aggressive behavior

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medicine(all)

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