Effects of atrial pacing on arterial and coronary sinus endothelin-1 levels in syndrome X

Gaetano A. Lanza, Thomas F. Lüscher, Vincenzo Pasceri, Sidney G. Shaw, Antonino Buffon, Annibale S. Montenero, Filippo Crea, Attilio Maseri

Research output: Contribution to journalArticlepeer-review

Abstract

Syndrome X may be caused by a coronary microvascular dysfunction, possibly due to abnormalities in coronary endothelial function. Previous studies suggested that endothelin-1 (ET-1) might be involved in the pathogenesis of syndrome X. Baseline arterial and coronary sinus ET-1 levels were measured in 13 patients with syndrome X (10 women, 52 ± 7 years) and in 8 control patients (5 women, 46 ± 11 years). ET-1 was also measured after atrial pacing in 12 patients with syndrome X and all controls. To simultaneously assess the activity of nitric oxide, guanosine 3'-5'-cyclic monophosphate (cGMP) was also measured in 11 patients with syndrome X and 7 controls. Baseline arterial (2.27 ± 0.46 vs 1.90 ± 0.22 pg/ml, p

Original languageEnglish
Pages (from-to)1187-1191
Number of pages5
JournalThe American Journal of Cardiology
Volume84
Issue number10
DOIs
Publication statusPublished - Nov 18 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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