Effects of balloon angioplasty and stent implantation on intrarenal echo-Doppler velocimetric indices

Ivana Marana, Flavio Airoldi, Larry Burdick, Cristina Alberti, Andrea Lovaria, Silvia Saccheri, Gabriella Gazzano, Simone Palatresi, Barbara Nador, Lucia Turolo, Alberto Morganti

Research output: Contribution to journalArticle

Abstract

This study was aimed at examining whether four intrarenal echo-Doppler velocimetric indices (pulsatility and resistive indices, acceleration and acceleration time) can be useful for assessing the effects of renal artery dilation obtained with either angioplasty or stent implantation. Echo- Doppler studies were performed in 63 hypertensive patients with 68 renal artery stenoses (39 atherosclerotic and 29 fibromuscular) prior to and within five days after the dilation procedures (55 angioplasties, 13 stent implantations), which resulted in an average reduction of arterial narrowing from 79% to 20%. In 24 patients, the velocimetric indices were also examined in relationship to the venoarterial differences of plasma renin activity and of angiotensin II across the stenotic kidneys. We found that after dilation the values of the four indices had returned within the normal range in all but three arteries (one false negative for resistive index and two for acceleration time). However, decrements in acceleration time was the only factor to be significantly correlated with the reduction of arterial narrowing. Moreover, postdilation values of this index were, on average, slightly but significantly higher in arteries that at follow-up developed restenosis rather than in those that remained patent. For similar reductions in arterial narrowing the absolute changes of all indices were similar in atherosclerotic and fibromuscular stenotic arteries and, in a subset of the atheromatous arteries, were also similar after angioplasty and stent implantation. No relationship was found with the changes in the venoarterial differences of plasma renin activity and angiotensin II. It appears that these intrarenal velocimetric indices and, in particular, acceleration time reliably reflect the technical success of renal artery dilation. The acceleration time index may also be valuable for predicting the restenosis of the dilated vessel. None of the indices, however, mirrors the functional consequences of removal of renal artery stenosis as expressed through the changes in transrenal gradients of the components of the renin-angiotensin system.

Original languageEnglish
Pages (from-to)1795-1800
Number of pages6
JournalKidney International
Volume53
Issue number6
DOIs
Publication statusPublished - 1998

Fingerprint

Balloon Angioplasty
Stents
Dilatation
Arteries
Angioplasty
Renal Artery Obstruction
Renal Artery
Renin
Angiotensin II
Renin-Angiotensin System
Reference Values
Kidney

Keywords

  • Angiotensin II
  • Atherosclerotic stenosis
  • Fibromuscular renal artery stenosis
  • Plasma renin activity

ASJC Scopus subject areas

  • Nephrology

Cite this

Effects of balloon angioplasty and stent implantation on intrarenal echo-Doppler velocimetric indices. / Marana, Ivana; Airoldi, Flavio; Burdick, Larry; Alberti, Cristina; Lovaria, Andrea; Saccheri, Silvia; Gazzano, Gabriella; Palatresi, Simone; Nador, Barbara; Turolo, Lucia; Morganti, Alberto.

In: Kidney International, Vol. 53, No. 6, 1998, p. 1795-1800.

Research output: Contribution to journalArticle

Marana, I, Airoldi, F, Burdick, L, Alberti, C, Lovaria, A, Saccheri, S, Gazzano, G, Palatresi, S, Nador, B, Turolo, L & Morganti, A 1998, 'Effects of balloon angioplasty and stent implantation on intrarenal echo-Doppler velocimetric indices', Kidney International, vol. 53, no. 6, pp. 1795-1800. https://doi.org/10.1046/j.1523-1755.1998.00941.x
Marana, Ivana ; Airoldi, Flavio ; Burdick, Larry ; Alberti, Cristina ; Lovaria, Andrea ; Saccheri, Silvia ; Gazzano, Gabriella ; Palatresi, Simone ; Nador, Barbara ; Turolo, Lucia ; Morganti, Alberto. / Effects of balloon angioplasty and stent implantation on intrarenal echo-Doppler velocimetric indices. In: Kidney International. 1998 ; Vol. 53, No. 6. pp. 1795-1800.
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abstract = "This study was aimed at examining whether four intrarenal echo-Doppler velocimetric indices (pulsatility and resistive indices, acceleration and acceleration time) can be useful for assessing the effects of renal artery dilation obtained with either angioplasty or stent implantation. Echo- Doppler studies were performed in 63 hypertensive patients with 68 renal artery stenoses (39 atherosclerotic and 29 fibromuscular) prior to and within five days after the dilation procedures (55 angioplasties, 13 stent implantations), which resulted in an average reduction of arterial narrowing from 79{\%} to 20{\%}. In 24 patients, the velocimetric indices were also examined in relationship to the venoarterial differences of plasma renin activity and of angiotensin II across the stenotic kidneys. We found that after dilation the values of the four indices had returned within the normal range in all but three arteries (one false negative for resistive index and two for acceleration time). However, decrements in acceleration time was the only factor to be significantly correlated with the reduction of arterial narrowing. Moreover, postdilation values of this index were, on average, slightly but significantly higher in arteries that at follow-up developed restenosis rather than in those that remained patent. For similar reductions in arterial narrowing the absolute changes of all indices were similar in atherosclerotic and fibromuscular stenotic arteries and, in a subset of the atheromatous arteries, were also similar after angioplasty and stent implantation. No relationship was found with the changes in the venoarterial differences of plasma renin activity and angiotensin II. It appears that these intrarenal velocimetric indices and, in particular, acceleration time reliably reflect the technical success of renal artery dilation. The acceleration time index may also be valuable for predicting the restenosis of the dilated vessel. None of the indices, however, mirrors the functional consequences of removal of renal artery stenosis as expressed through the changes in transrenal gradients of the components of the renin-angiotensin system.",
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AU - Saccheri, Silvia

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