Abstract
An abnormal stimulation of adenosine A1-receptors has been suggested to play a role in the pathogenesis of both chest pain and ischemia-like electrocardiographic changes in patients with syndrome X and a nonselective adenosine antagonist (theophylline) has been reported to be beneficial in these patients. In this study we investigated the acute effects of bamiphylline, a specific A1-receptor antagonist, in 16 patients with syndrome X (14 women, age 57 ± 6 years), with both angina and ST-segment depression inducible during exercise testing. All patients underwent two treadmill exercise tests (Bruce modified protocol) on 2 separate days, 5 minutes after the end of randomized intravenous infusion of either placebo (saline solution) or bamiphylline (300 mg). Severity of chest pain was assessed by a 10 mm visual analogic scale. There were no significant differences in resting heart rate and blood pressure after bamiphylline or placebo. Rate-pressure product (20600 ± 5000 vs 20200 ± 5200 bpm · mmHg), time to 1 mm ST depression (549 ± 196 vs 581 ± 201 sec), time to angina (519 ± 209 vs 571 ± 196 sec), and exercise duration (717 ± 134 vs 676 ± 166 sec) were also not significantly different after bamiphylline or placebo, but there was a mild reduction of the severity of exercise-induced chest pain (30 ± 22 vs 39 ± 20 mm, p <0.05) with the active drug. Thus, in patients with syndrome X, bamiphylline does not improve exercise-induced ST changes, suggesting that A1-receptors are not significantly involved in their appearance. In addition, bamiphylline had little effect on anginal pain, suggesting that this cannot be mediated exclusively by A1-receptor stimulation in these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 50-54 |
| Number of pages | 5 |
| Journal | Giornale Italiano di Cardiologia |
| Volume | 27 |
| Issue number | 1 |
| Publication status | Published - Jan 1997 |
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Keywords
- bamiphylline
- exercise testing
- syndrome X
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Effects of bamiphylline on exercise testing in patients with syndrome X. / Lanza, Gaetano A.; Gaspardone, Achille; Pasceri, Vincenzo; Perino, Michele; Colonna, Giuseppe; Tomai, Fabrizio; Crea, Filippo; Gioffrè, Pier A.; Maseri, Attilio.
In: Giornale Italiano di Cardiologia, Vol. 27, No. 1, 01.1997, p. 50-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of bamiphylline on exercise testing in patients with syndrome X
AU - Lanza, Gaetano A.
AU - Gaspardone, Achille
AU - Pasceri, Vincenzo
AU - Perino, Michele
AU - Colonna, Giuseppe
AU - Tomai, Fabrizio
AU - Crea, Filippo
AU - Gioffrè, Pier A.
AU - Maseri, Attilio
PY - 1997/1
Y1 - 1997/1
N2 - An abnormal stimulation of adenosine A1-receptors has been suggested to play a role in the pathogenesis of both chest pain and ischemia-like electrocardiographic changes in patients with syndrome X and a nonselective adenosine antagonist (theophylline) has been reported to be beneficial in these patients. In this study we investigated the acute effects of bamiphylline, a specific A1-receptor antagonist, in 16 patients with syndrome X (14 women, age 57 ± 6 years), with both angina and ST-segment depression inducible during exercise testing. All patients underwent two treadmill exercise tests (Bruce modified protocol) on 2 separate days, 5 minutes after the end of randomized intravenous infusion of either placebo (saline solution) or bamiphylline (300 mg). Severity of chest pain was assessed by a 10 mm visual analogic scale. There were no significant differences in resting heart rate and blood pressure after bamiphylline or placebo. Rate-pressure product (20600 ± 5000 vs 20200 ± 5200 bpm · mmHg), time to 1 mm ST depression (549 ± 196 vs 581 ± 201 sec), time to angina (519 ± 209 vs 571 ± 196 sec), and exercise duration (717 ± 134 vs 676 ± 166 sec) were also not significantly different after bamiphylline or placebo, but there was a mild reduction of the severity of exercise-induced chest pain (30 ± 22 vs 39 ± 20 mm, p <0.05) with the active drug. Thus, in patients with syndrome X, bamiphylline does not improve exercise-induced ST changes, suggesting that A1-receptors are not significantly involved in their appearance. In addition, bamiphylline had little effect on anginal pain, suggesting that this cannot be mediated exclusively by A1-receptor stimulation in these patients.
AB - An abnormal stimulation of adenosine A1-receptors has been suggested to play a role in the pathogenesis of both chest pain and ischemia-like electrocardiographic changes in patients with syndrome X and a nonselective adenosine antagonist (theophylline) has been reported to be beneficial in these patients. In this study we investigated the acute effects of bamiphylline, a specific A1-receptor antagonist, in 16 patients with syndrome X (14 women, age 57 ± 6 years), with both angina and ST-segment depression inducible during exercise testing. All patients underwent two treadmill exercise tests (Bruce modified protocol) on 2 separate days, 5 minutes after the end of randomized intravenous infusion of either placebo (saline solution) or bamiphylline (300 mg). Severity of chest pain was assessed by a 10 mm visual analogic scale. There were no significant differences in resting heart rate and blood pressure after bamiphylline or placebo. Rate-pressure product (20600 ± 5000 vs 20200 ± 5200 bpm · mmHg), time to 1 mm ST depression (549 ± 196 vs 581 ± 201 sec), time to angina (519 ± 209 vs 571 ± 196 sec), and exercise duration (717 ± 134 vs 676 ± 166 sec) were also not significantly different after bamiphylline or placebo, but there was a mild reduction of the severity of exercise-induced chest pain (30 ± 22 vs 39 ± 20 mm, p <0.05) with the active drug. Thus, in patients with syndrome X, bamiphylline does not improve exercise-induced ST changes, suggesting that A1-receptors are not significantly involved in their appearance. In addition, bamiphylline had little effect on anginal pain, suggesting that this cannot be mediated exclusively by A1-receptor stimulation in these patients.
KW - bamiphylline
KW - exercise testing
KW - syndrome X
UR - http://www.scopus.com/inward/record.url?scp=0030944681&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030944681&partnerID=8YFLogxK
M3 - Article
C2 - 9199943
AN - SCOPUS:0030944681
VL - 27
SP - 50
EP - 54
JO - Giornale Italiano di Cardiologia
JF - Giornale Italiano di Cardiologia
SN - 0046-5968
IS - 1
ER -