Effects of bamiphylline on exercise testing in patients with syndrome X

Gaetano A. Lanza, Achille Gaspardone, Vincenzo Pasceri, Michele Perino, Giuseppe Colonna, Fabrizio Tomai, Filippo Crea, Pier A. Gioffrè, Attilio Maseri

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

An abnormal stimulation of adenosine A1-receptors has been suggested to play a role in the pathogenesis of both chest pain and ischemia-like electrocardiographic changes in patients with syndrome X and a nonselective adenosine antagonist (theophylline) has been reported to be beneficial in these patients. In this study we investigated the acute effects of bamiphylline, a specific A1-receptor antagonist, in 16 patients with syndrome X (14 women, age 57 ± 6 years), with both angina and ST-segment depression inducible during exercise testing. All patients underwent two treadmill exercise tests (Bruce modified protocol) on 2 separate days, 5 minutes after the end of randomized intravenous infusion of either placebo (saline solution) or bamiphylline (300 mg). Severity of chest pain was assessed by a 10 mm visual analogic scale. There were no significant differences in resting heart rate and blood pressure after bamiphylline or placebo. Rate-pressure product (20600 ± 5000 vs 20200 ± 5200 bpm · mmHg), time to 1 mm ST depression (549 ± 196 vs 581 ± 201 sec), time to angina (519 ± 209 vs 571 ± 196 sec), and exercise duration (717 ± 134 vs 676 ± 166 sec) were also not significantly different after bamiphylline or placebo, but there was a mild reduction of the severity of exercise-induced chest pain (30 ± 22 vs 39 ± 20 mm, p <0.05) with the active drug. Thus, in patients with syndrome X, bamiphylline does not improve exercise-induced ST changes, suggesting that A1-receptors are not significantly involved in their appearance. In addition, bamiphylline had little effect on anginal pain, suggesting that this cannot be mediated exclusively by A1-receptor stimulation in these patients.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalGiornale Italiano di Cardiologia
Volume27
Issue number1
Publication statusPublished - Jan 1997

Fingerprint

Exercise
Chest Pain
Placebos
Exercise Test
Adenosine A1 Receptors
Theophylline
Intravenous Infusions
Sodium Chloride
Adenosine
bamifylline
Ischemia
Heart Rate
Blood Pressure
Pressure
Pain
Pharmaceutical Preparations

Keywords

  • bamiphylline
  • exercise testing
  • syndrome X

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lanza, G. A., Gaspardone, A., Pasceri, V., Perino, M., Colonna, G., Tomai, F., ... Maseri, A. (1997). Effects of bamiphylline on exercise testing in patients with syndrome X. Giornale Italiano di Cardiologia, 27(1), 50-54.

Effects of bamiphylline on exercise testing in patients with syndrome X. / Lanza, Gaetano A.; Gaspardone, Achille; Pasceri, Vincenzo; Perino, Michele; Colonna, Giuseppe; Tomai, Fabrizio; Crea, Filippo; Gioffrè, Pier A.; Maseri, Attilio.

In: Giornale Italiano di Cardiologia, Vol. 27, No. 1, 01.1997, p. 50-54.

Research output: Contribution to journalArticle

Lanza, GA, Gaspardone, A, Pasceri, V, Perino, M, Colonna, G, Tomai, F, Crea, F, Gioffrè, PA & Maseri, A 1997, 'Effects of bamiphylline on exercise testing in patients with syndrome X', Giornale Italiano di Cardiologia, vol. 27, no. 1, pp. 50-54.
Lanza GA, Gaspardone A, Pasceri V, Perino M, Colonna G, Tomai F et al. Effects of bamiphylline on exercise testing in patients with syndrome X. Giornale Italiano di Cardiologia. 1997 Jan;27(1):50-54.
Lanza, Gaetano A. ; Gaspardone, Achille ; Pasceri, Vincenzo ; Perino, Michele ; Colonna, Giuseppe ; Tomai, Fabrizio ; Crea, Filippo ; Gioffrè, Pier A. ; Maseri, Attilio. / Effects of bamiphylline on exercise testing in patients with syndrome X. In: Giornale Italiano di Cardiologia. 1997 ; Vol. 27, No. 1. pp. 50-54.
@article{910ea8b1ad284fb1b1e6a417478bd625,
title = "Effects of bamiphylline on exercise testing in patients with syndrome X",
abstract = "An abnormal stimulation of adenosine A1-receptors has been suggested to play a role in the pathogenesis of both chest pain and ischemia-like electrocardiographic changes in patients with syndrome X and a nonselective adenosine antagonist (theophylline) has been reported to be beneficial in these patients. In this study we investigated the acute effects of bamiphylline, a specific A1-receptor antagonist, in 16 patients with syndrome X (14 women, age 57 ± 6 years), with both angina and ST-segment depression inducible during exercise testing. All patients underwent two treadmill exercise tests (Bruce modified protocol) on 2 separate days, 5 minutes after the end of randomized intravenous infusion of either placebo (saline solution) or bamiphylline (300 mg). Severity of chest pain was assessed by a 10 mm visual analogic scale. There were no significant differences in resting heart rate and blood pressure after bamiphylline or placebo. Rate-pressure product (20600 ± 5000 vs 20200 ± 5200 bpm · mmHg), time to 1 mm ST depression (549 ± 196 vs 581 ± 201 sec), time to angina (519 ± 209 vs 571 ± 196 sec), and exercise duration (717 ± 134 vs 676 ± 166 sec) were also not significantly different after bamiphylline or placebo, but there was a mild reduction of the severity of exercise-induced chest pain (30 ± 22 vs 39 ± 20 mm, p <0.05) with the active drug. Thus, in patients with syndrome X, bamiphylline does not improve exercise-induced ST changes, suggesting that A1-receptors are not significantly involved in their appearance. In addition, bamiphylline had little effect on anginal pain, suggesting that this cannot be mediated exclusively by A1-receptor stimulation in these patients.",
keywords = "bamiphylline, exercise testing, syndrome X",
author = "Lanza, {Gaetano A.} and Achille Gaspardone and Vincenzo Pasceri and Michele Perino and Giuseppe Colonna and Fabrizio Tomai and Filippo Crea and Gioffr{\`e}, {Pier A.} and Attilio Maseri",
year = "1997",
month = "1",
language = "English",
volume = "27",
pages = "50--54",
journal = "Giornale Italiano di Cardiologia",
issn = "0046-5968",
publisher = "Societa Italiana di Cardiologia",
number = "1",

}

TY - JOUR

T1 - Effects of bamiphylline on exercise testing in patients with syndrome X

AU - Lanza, Gaetano A.

AU - Gaspardone, Achille

AU - Pasceri, Vincenzo

AU - Perino, Michele

AU - Colonna, Giuseppe

AU - Tomai, Fabrizio

AU - Crea, Filippo

AU - Gioffrè, Pier A.

AU - Maseri, Attilio

PY - 1997/1

Y1 - 1997/1

N2 - An abnormal stimulation of adenosine A1-receptors has been suggested to play a role in the pathogenesis of both chest pain and ischemia-like electrocardiographic changes in patients with syndrome X and a nonselective adenosine antagonist (theophylline) has been reported to be beneficial in these patients. In this study we investigated the acute effects of bamiphylline, a specific A1-receptor antagonist, in 16 patients with syndrome X (14 women, age 57 ± 6 years), with both angina and ST-segment depression inducible during exercise testing. All patients underwent two treadmill exercise tests (Bruce modified protocol) on 2 separate days, 5 minutes after the end of randomized intravenous infusion of either placebo (saline solution) or bamiphylline (300 mg). Severity of chest pain was assessed by a 10 mm visual analogic scale. There were no significant differences in resting heart rate and blood pressure after bamiphylline or placebo. Rate-pressure product (20600 ± 5000 vs 20200 ± 5200 bpm · mmHg), time to 1 mm ST depression (549 ± 196 vs 581 ± 201 sec), time to angina (519 ± 209 vs 571 ± 196 sec), and exercise duration (717 ± 134 vs 676 ± 166 sec) were also not significantly different after bamiphylline or placebo, but there was a mild reduction of the severity of exercise-induced chest pain (30 ± 22 vs 39 ± 20 mm, p <0.05) with the active drug. Thus, in patients with syndrome X, bamiphylline does not improve exercise-induced ST changes, suggesting that A1-receptors are not significantly involved in their appearance. In addition, bamiphylline had little effect on anginal pain, suggesting that this cannot be mediated exclusively by A1-receptor stimulation in these patients.

AB - An abnormal stimulation of adenosine A1-receptors has been suggested to play a role in the pathogenesis of both chest pain and ischemia-like electrocardiographic changes in patients with syndrome X and a nonselective adenosine antagonist (theophylline) has been reported to be beneficial in these patients. In this study we investigated the acute effects of bamiphylline, a specific A1-receptor antagonist, in 16 patients with syndrome X (14 women, age 57 ± 6 years), with both angina and ST-segment depression inducible during exercise testing. All patients underwent two treadmill exercise tests (Bruce modified protocol) on 2 separate days, 5 minutes after the end of randomized intravenous infusion of either placebo (saline solution) or bamiphylline (300 mg). Severity of chest pain was assessed by a 10 mm visual analogic scale. There were no significant differences in resting heart rate and blood pressure after bamiphylline or placebo. Rate-pressure product (20600 ± 5000 vs 20200 ± 5200 bpm · mmHg), time to 1 mm ST depression (549 ± 196 vs 581 ± 201 sec), time to angina (519 ± 209 vs 571 ± 196 sec), and exercise duration (717 ± 134 vs 676 ± 166 sec) were also not significantly different after bamiphylline or placebo, but there was a mild reduction of the severity of exercise-induced chest pain (30 ± 22 vs 39 ± 20 mm, p <0.05) with the active drug. Thus, in patients with syndrome X, bamiphylline does not improve exercise-induced ST changes, suggesting that A1-receptors are not significantly involved in their appearance. In addition, bamiphylline had little effect on anginal pain, suggesting that this cannot be mediated exclusively by A1-receptor stimulation in these patients.

KW - bamiphylline

KW - exercise testing

KW - syndrome X

UR - http://www.scopus.com/inward/record.url?scp=0030944681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030944681&partnerID=8YFLogxK

M3 - Article

C2 - 9199943

AN - SCOPUS:0030944681

VL - 27

SP - 50

EP - 54

JO - Giornale Italiano di Cardiologia

JF - Giornale Italiano di Cardiologia

SN - 0046-5968

IS - 1

ER -