TY - JOUR
T1 - Effects of bergamot polyphenols on mitochondrial dysfunction and sarcoplasmic reticulum stress in diabetic cardiomyopathy
AU - Maiuolo, Jessica
AU - Carresi, Cristina
AU - Gliozzi, Micaela
AU - Musolino, Vincenzo
AU - Scarano, Federica
AU - Coppoletta, Anna Rita
AU - Guarnieri, Lorenza
AU - Nucera, Saverio
AU - Scicchitano, Miriam
AU - Bosco, Francesca
AU - Ruga, Stefano
AU - Zito, Maria Caterina
AU - Macri, Roberta
AU - Cardamone, Antonio
AU - Serra, Maria
AU - Mollace, Rocco
AU - Tavernese, Annamaria
AU - Mollace, Vincenzo
N1 - Funding Information:
Acknowledgments: This work was supported by PON-MIUR 03PE000_78_1 and PONMIUR 03PE000 _78_2.
Funding Information:
Funding: The work was supported by the public resources from the Italian Ministry of Research.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/7
Y1 - 2021/7
N2 - Cardiovascular disease is the leading cause of death and disability in the Western world. In order to safeguard the structure and the functionality of the myocardium, it is extremely important to adequately support the cardiomyocytes. Two cellular organelles of cardiomyocytes are essential for cell survival and to ensure proper functioning of the myocardium: mitochondria and the sarcoplasmic reticulum. Mitochondria are responsible for the energy metabolism of the myocardium, and regulate the processes that can lead to cell death. The sarcoplasmic reticulum preserves the physiological concentration of the calcium ion, and triggers processes to protect the structural and functional integrity of the proteins. The alterations of these organelles can damage myocardial functioning. A proper nutritional balance regarding the intake of macronutrients and micronutrients leads to a significant improvement in the symptoms and consequences of heart disease. In particular, the Mediterranean diet, characterized by a high consumption of plant-based foods, small quantities of red meat, and high quantities of olive oil, reduces and improves the pathological condition of patients with heart failure. In addition, nutritional support and nutraceutical supplementation in patients who develop heart failure can contribute to the protection of the failing myocardium. Since polyphenols have numerous beneficial properties, including anti-inflammatory and antioxidant properties, this review gathers what is known about the beneficial effects of polyphenol-rich bergamot fruit on the cardiovascular system. In particular, the role of bergamot polyphenols in mitochondrial and sarcoplasmic dysfunctions in diabetic cardiomyopathy is reported.
AB - Cardiovascular disease is the leading cause of death and disability in the Western world. In order to safeguard the structure and the functionality of the myocardium, it is extremely important to adequately support the cardiomyocytes. Two cellular organelles of cardiomyocytes are essential for cell survival and to ensure proper functioning of the myocardium: mitochondria and the sarcoplasmic reticulum. Mitochondria are responsible for the energy metabolism of the myocardium, and regulate the processes that can lead to cell death. The sarcoplasmic reticulum preserves the physiological concentration of the calcium ion, and triggers processes to protect the structural and functional integrity of the proteins. The alterations of these organelles can damage myocardial functioning. A proper nutritional balance regarding the intake of macronutrients and micronutrients leads to a significant improvement in the symptoms and consequences of heart disease. In particular, the Mediterranean diet, characterized by a high consumption of plant-based foods, small quantities of red meat, and high quantities of olive oil, reduces and improves the pathological condition of patients with heart failure. In addition, nutritional support and nutraceutical supplementation in patients who develop heart failure can contribute to the protection of the failing myocardium. Since polyphenols have numerous beneficial properties, including anti-inflammatory and antioxidant properties, this review gathers what is known about the beneficial effects of polyphenol-rich bergamot fruit on the cardiovascular system. In particular, the role of bergamot polyphenols in mitochondrial and sarcoplasmic dysfunctions in diabetic cardiomyopathy is reported.
KW - Bergamot polyphenolic fraction
KW - Bergamot polyphenols
KW - Diabetic cardiomyopathy
KW - Myocardial dysfunction
KW - Myocardial metabolism
KW - Role of mitochondria and sarcoplasmic reticulum in the myocardium
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U2 - 10.3390/nu13072476
DO - 10.3390/nu13072476
M3 - Review article
C2 - 34371986
AN - SCOPUS:85110465448
VL - 13
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 7
M1 - 2476
ER -