Abstract
Background: Chronic bilateral subthalamic deep brain stimulation (STN-DBS) is known to improve motor function in patients with Parkinson disease (PD). However, the possible effects of STN-DBS on neuropsychological functions have been studied less. Objective: To investigate the effects of STN-DBS on neuropsychological functions in PD. Design: Before-after trial. Patients and Methods: Fifteen consecutive patients were assessed before and 3 months after implantation of stimulators for STN-DBS (postsurgical assessment with the stimulators switched on). Both assessments were performed with patients in a drug-free condition. The neuropsychological battery consisted of tests measuring memory and visuospatial and frontal functions. Results: The comparison between presurgical and postsurgical performance showed a moderate deterioration in verbal memory and prefrontal and visuospatial functions, and a moderate improvement in a prefrontal task and obsessive-compulsive traits. The motor state improved in all patients. Conclusion: Therapy with STN-DBS improves motor symptoms in PD without any clinically relevant neuropsychological deterioration.
| Original language | English |
|---|---|
| Pages (from-to) | 1223-1227 |
| Number of pages | 5 |
| Journal | Archives of Neurology |
| Volume | 58 |
| Issue number | 8 |
| Publication status | Published - 2001 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease. / Alegret, Montse; Junqué, Carme; Valldeoriola, Francesc; Vendrell, Pere; Pilleri, Manuela; Rumià, Jordi; Tolosa, Eduardo.
In: Archives of Neurology, Vol. 58, No. 8, 2001, p. 1223-1227.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease
AU - Alegret, Montse
AU - Junqué, Carme
AU - Valldeoriola, Francesc
AU - Vendrell, Pere
AU - Pilleri, Manuela
AU - Rumià, Jordi
AU - Tolosa, Eduardo
PY - 2001
Y1 - 2001
N2 - Background: Chronic bilateral subthalamic deep brain stimulation (STN-DBS) is known to improve motor function in patients with Parkinson disease (PD). However, the possible effects of STN-DBS on neuropsychological functions have been studied less. Objective: To investigate the effects of STN-DBS on neuropsychological functions in PD. Design: Before-after trial. Patients and Methods: Fifteen consecutive patients were assessed before and 3 months after implantation of stimulators for STN-DBS (postsurgical assessment with the stimulators switched on). Both assessments were performed with patients in a drug-free condition. The neuropsychological battery consisted of tests measuring memory and visuospatial and frontal functions. Results: The comparison between presurgical and postsurgical performance showed a moderate deterioration in verbal memory and prefrontal and visuospatial functions, and a moderate improvement in a prefrontal task and obsessive-compulsive traits. The motor state improved in all patients. Conclusion: Therapy with STN-DBS improves motor symptoms in PD without any clinically relevant neuropsychological deterioration.
AB - Background: Chronic bilateral subthalamic deep brain stimulation (STN-DBS) is known to improve motor function in patients with Parkinson disease (PD). However, the possible effects of STN-DBS on neuropsychological functions have been studied less. Objective: To investigate the effects of STN-DBS on neuropsychological functions in PD. Design: Before-after trial. Patients and Methods: Fifteen consecutive patients were assessed before and 3 months after implantation of stimulators for STN-DBS (postsurgical assessment with the stimulators switched on). Both assessments were performed with patients in a drug-free condition. The neuropsychological battery consisted of tests measuring memory and visuospatial and frontal functions. Results: The comparison between presurgical and postsurgical performance showed a moderate deterioration in verbal memory and prefrontal and visuospatial functions, and a moderate improvement in a prefrontal task and obsessive-compulsive traits. The motor state improved in all patients. Conclusion: Therapy with STN-DBS improves motor symptoms in PD without any clinically relevant neuropsychological deterioration.
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M3 - Article
VL - 58
SP - 1223
EP - 1227
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 8
ER -