Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease

Montse Alegret, Carme Junqué, Francesc Valldeoriola, Pere Vendrell, Manuela Pilleri, Jordi Rumià, Eduardo Tolosa

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

Background: Chronic bilateral subthalamic deep brain stimulation (STN-DBS) is known to improve motor function in patients with Parkinson disease (PD). However, the possible effects of STN-DBS on neuropsychological functions have been studied less. Objective: To investigate the effects of STN-DBS on neuropsychological functions in PD. Design: Before-after trial. Patients and Methods: Fifteen consecutive patients were assessed before and 3 months after implantation of stimulators for STN-DBS (postsurgical assessment with the stimulators switched on). Both assessments were performed with patients in a drug-free condition. The neuropsychological battery consisted of tests measuring memory and visuospatial and frontal functions. Results: The comparison between presurgical and postsurgical performance showed a moderate deterioration in verbal memory and prefrontal and visuospatial functions, and a moderate improvement in a prefrontal task and obsessive-compulsive traits. The motor state improved in all patients. Conclusion: Therapy with STN-DBS improves motor symptoms in PD without any clinically relevant neuropsychological deterioration.

Original languageEnglish
Pages (from-to)1223-1227
Number of pages5
JournalArchives of Neurology
Volume58
Issue number8
Publication statusPublished - 2001

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Cognition
Parkinson Disease
Deep Brain Stimulation
Parkinson's Disease
Cognitive Function
Stimulation
Pharmaceutical Preparations
Deterioration
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alegret, M., Junqué, C., Valldeoriola, F., Vendrell, P., Pilleri, M., Rumià, J., & Tolosa, E. (2001). Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease. Archives of Neurology, 58(8), 1223-1227.

Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease. / Alegret, Montse; Junqué, Carme; Valldeoriola, Francesc; Vendrell, Pere; Pilleri, Manuela; Rumià, Jordi; Tolosa, Eduardo.

In: Archives of Neurology, Vol. 58, No. 8, 2001, p. 1223-1227.

Research output: Contribution to journalArticle

Alegret, M, Junqué, C, Valldeoriola, F, Vendrell, P, Pilleri, M, Rumià, J & Tolosa, E 2001, 'Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease', Archives of Neurology, vol. 58, no. 8, pp. 1223-1227.
Alegret M, Junqué C, Valldeoriola F, Vendrell P, Pilleri M, Rumià J et al. Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease. Archives of Neurology. 2001;58(8):1223-1227.
Alegret, Montse ; Junqué, Carme ; Valldeoriola, Francesc ; Vendrell, Pere ; Pilleri, Manuela ; Rumià, Jordi ; Tolosa, Eduardo. / Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease. In: Archives of Neurology. 2001 ; Vol. 58, No. 8. pp. 1223-1227.
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