Effects of blood pressure lowering on outcome incidence in hypertension: 3. Effects in patients at different levels of cardiovascular risk - Overview and meta-analyses of randomized trials

Costas Thomopoulos, Gianfranco Parati, Alberto Zanchetti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Randomized controlled trials (RCTs) of blood pressure (BP) lowering lend themselves to be meta-analyzed to help providing evidence-based recommendations for hypertension treatment. Objectives: To investigate whether relative or absolute risk reductions increase at increasing levels of baseline cardiovascular risk and whether BP-lowering treatment should be addressed to patients in risk categories promising larger absolute treatment benefits. Methods: Sixty-eight RCTs of intentional and nonintentional BP lowering were classified in four strata of increasing average 10-year incidence of cardiovascular death in the placebo or less active treatment group: lowto- moderate risk (

Original languageEnglish
Pages (from-to)2305-2314
Number of pages10
JournalJournal of Hypertension
Volume32
Issue number12
DOIs
Publication statusPublished - 2014

Keywords

  • Blood-pressure-lowering treatment
  • Cardiovascular risk
  • Hypertension
  • Meta-analysis
  • Randomized controlled trials
  • Residual risk

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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