Effects of botulinum toxin type A in the bladder wall of children with neurogenic bladder dysfunction: A comparison of histological features before and after injections

Maria Paola Pascali, Giovanni Mosiello, Renata Boldrini, Maria Letizia Salsano, Enrico Castelli, Mario De Gennaro

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Botulinum toxin type A has gained popularity in urology. Most reported studies have been in adults at urology centers and most have addressed long-term safety. Since botulinum toxin type A treatment for neurogenic bladder dysfunction requires repeat injections, verifying that such treatment does not induce fibrosis in children seems essential. Materials and Methods: The study was approved by the institutional review board and patients were enrolled after we obtained written consent. Patients with neurogenic bladder dysfunction not responding to conventional treatment (anticholinergics and clean intermittent catheterization) were treated with 10 IU/kg botulinum toxin type A up to a maximum of 300 IU. Endoscopic cold cup biopsies were obtained from the posterolateral bladder wall 1.5 to 2 cm above the ureteral orifice. Bladder wall findings were categorized into 3 groups, including inflammatory infiltration, edema and fibrosis. Each criterion was then graded as mild or severe and analyzed by Fisher's exact test (p

Original languageEnglish
Pages (from-to)2552-2557
Number of pages6
JournalJournal of Urology
Volume185
Issue number6 SUPPL.
DOIs
Publication statusPublished - Jun 2011

Keywords

  • botulinum toxin type A
  • fibrosis
  • inflammation
  • urinary bladder
  • urinary bladder neurogenic

ASJC Scopus subject areas

  • Urology

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