Effects of bromocriptine on central dopaminergic receptors

M. Trabucchi, P. F. Spano, G. C. Tonon, L. Frattola

Research output: Contribution to journalArticle

Abstract

Bromocriptine injected to rats induces an increase of cAMP levels in the striatum in vivo. The time course of this increase is very similar to that of apomorphine. However bromocriptine does not stimulate striatal dopamine-sensitive adenylate cyclase but surprisingly antagonized the activation of this enzyme elicited by dopamine. Possible hypotheses on various sites of action of the drug are discussed.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalLife Sciences
Volume19
Issue number2
DOIs
Publication statusPublished - Jul 15 1976

ASJC Scopus subject areas

  • Pharmacology

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    Trabucchi, M., Spano, P. F., Tonon, G. C., & Frattola, L. (1976). Effects of bromocriptine on central dopaminergic receptors. Life Sciences, 19(2), 225-232. https://doi.org/10.1016/0024-3205(76)90394-5