Effects of bromocriptine on central dopaminergic receptors

M. Trabucchi, P. F. Spano, G. C. Tonon, L. Frattola

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Bromocriptine injected to rats induces an increase of cAMP levels in the striatum in vivo. The time course of this increase is very similar to that of apomorphine. However bromocriptine does not stimulate striatal dopamine-sensitive adenylate cyclase but surprisingly antagonized the activation of this enzyme elicited by dopamine. Possible hypotheses on various sites of action of the drug are discussed.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalLife Sciences
Volume19
Issue number2
DOIs
Publication statusPublished - Jul 15 1976

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Bromocriptine
Dopamine
Corpus Striatum
Enzyme Activation
Apomorphine
Adenylyl Cyclases
Rats
Chemical activation
Enzymes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Trabucchi, M., Spano, P. F., Tonon, G. C., & Frattola, L. (1976). Effects of bromocriptine on central dopaminergic receptors. Life Sciences, 19(2), 225-232. https://doi.org/10.1016/0024-3205(76)90394-5

Effects of bromocriptine on central dopaminergic receptors. / Trabucchi, M.; Spano, P. F.; Tonon, G. C.; Frattola, L.

In: Life Sciences, Vol. 19, No. 2, 15.07.1976, p. 225-232.

Research output: Contribution to journalArticle

Trabucchi, M, Spano, PF, Tonon, GC & Frattola, L 1976, 'Effects of bromocriptine on central dopaminergic receptors', Life Sciences, vol. 19, no. 2, pp. 225-232. https://doi.org/10.1016/0024-3205(76)90394-5
Trabucchi, M. ; Spano, P. F. ; Tonon, G. C. ; Frattola, L. / Effects of bromocriptine on central dopaminergic receptors. In: Life Sciences. 1976 ; Vol. 19, No. 2. pp. 225-232.
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