Effects of cadmium on lymphocyte activation

Maria Grazia Cifone, Edoardo Alesse, Antonio Procopio, Rossella Paolini, Stefania Morrone, Renato Di Eugenio, Giorgio Santoni, Angela Santoni

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The effects of cadmium (Cd) on phytohemoagglutinin or phorbol myristate acetate-induced lymphocyte activation were investigated and a dose-dependent inhibition of cell proliferation was found. Kinetic studies revealed that the Cd-sensitive step is an early event of T cell stimulation. Failure of IL2 secretion and reduction of IL2 receptor expression in the Cd-treated cells are also reported. Regardless of which mechanism is responsible for Cd effects, our studies show that the inhibition of lymphocyte activation is associated with reduced [3H]phorbol dibutyrate binding to Ca2+-phospholipid-dependent protein kinase and altered breakdown of phosphatidylinositols. Thus, Cd interferes with two biochemical events which play a critical role in lymphocyte signal transduction and activation.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1011
Issue number1
DOIs
Publication statusPublished - Mar 28 1989

Fingerprint

Lymphocyte Activation
Cadmium
Interleukin-2 Receptors
Tetradecanoylphorbol Acetate
Phosphatidylinositols
Protein Kinases
Interleukin-2
Signal Transduction
Phospholipids
Cell Proliferation
Lymphocytes
T-Lymphocytes

Keywords

  • (Human)
  • Cadmium
  • Interleukin 2
  • Phosphatidylinositol hydrolysis
  • Protein kinase C
  • T cell activation

ASJC Scopus subject areas

  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Cifone, M. G., Alesse, E., Procopio, A., Paolini, R., Morrone, S., Di Eugenio, R., ... Santoni, A. (1989). Effects of cadmium on lymphocyte activation. Biochimica et Biophysica Acta - Molecular Cell Research, 1011(1), 25-32. https://doi.org/10.1016/0167-4889(89)90073-6

Effects of cadmium on lymphocyte activation. / Cifone, Maria Grazia; Alesse, Edoardo; Procopio, Antonio; Paolini, Rossella; Morrone, Stefania; Di Eugenio, Renato; Santoni, Giorgio; Santoni, Angela.

In: Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1011, No. 1, 28.03.1989, p. 25-32.

Research output: Contribution to journalArticle

Cifone, MG, Alesse, E, Procopio, A, Paolini, R, Morrone, S, Di Eugenio, R, Santoni, G & Santoni, A 1989, 'Effects of cadmium on lymphocyte activation', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1011, no. 1, pp. 25-32. https://doi.org/10.1016/0167-4889(89)90073-6
Cifone, Maria Grazia ; Alesse, Edoardo ; Procopio, Antonio ; Paolini, Rossella ; Morrone, Stefania ; Di Eugenio, Renato ; Santoni, Giorgio ; Santoni, Angela. / Effects of cadmium on lymphocyte activation. In: Biochimica et Biophysica Acta - Molecular Cell Research. 1989 ; Vol. 1011, No. 1. pp. 25-32.
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