Effects of cadmium on lymphocyte activation

Maria Grazia Cifone, Edoardo Alesse, Antonio Procopio, Rossella Paolini, Stefania Morrone, Renato Di Eugenio, Giorgio Santoni, Angela Santoni

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of cadmium (Cd) on phytohemoagglutinin or phorbol myristate acetate-induced lymphocyte activation were investigated and a dose-dependent inhibition of cell proliferation was found. Kinetic studies revealed that the Cd-sensitive step is an early event of T cell stimulation. Failure of IL2 secretion and reduction of IL2 receptor expression in the Cd-treated cells are also reported. Regardless of which mechanism is responsible for Cd effects, our studies show that the inhibition of lymphocyte activation is associated with reduced [3H]phorbol dibutyrate binding to Ca2+-phospholipid-dependent protein kinase and altered breakdown of phosphatidylinositols. Thus, Cd interferes with two biochemical events which play a critical role in lymphocyte signal transduction and activation.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1011
Issue number1
DOIs
Publication statusPublished - Mar 28 1989

Keywords

  • (Human)
  • Cadmium
  • Interleukin 2
  • Phosphatidylinositol hydrolysis
  • Protein kinase C
  • T cell activation

ASJC Scopus subject areas

  • Biophysics
  • Cell Biology
  • Molecular Biology

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