Effects of calcitonin on the brain of aged rats

G. Clementi, A. Prato, R. Bernardini, F. Nicoletti, F. Patti, D. De Simone, U. Scapagnini

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We have recently demonstrated that calcitonin, a putative neuromodulator, may influence extrapyramidal motor system by decreasing nigro-striatal dopaminergic function. Since calcitonin is extensively used in aged patients, we have investigated whether calcitonin might influence extrapyramidal motor behavior (haloperidol-induced catalepsy and apomorphine-induced hyperactivity) in rats of different ages. Intracerebroventricular injection of salmon calcitonin (I μg/kg) prevented apomorphine-induced hyperactivity in 2, 7, 18 or 21 month old rats, but potentiated haloperidol-induced catalepsy only in 2 or 7 month old rats. In addition, in all the animals salmon calcitonin significantly decreased the secretion of prolactin, an anterior pituitary hormone that may act at central level enhancing nigro-striatal dopaminergic activity.

Original languageEnglish
Pages (from-to)229-232
Number of pages4
JournalNeurobiology of Aging
Volume4
Issue number3
DOIs
Publication statusPublished - 1983

Fingerprint

salmon calcitonin
Calcitonin
Catalepsy
Corpus Striatum
Apomorphine
Haloperidol
Brain
Anterior Pituitary Hormones
Prolactin
Neurotransmitter Agents
Injections

Keywords

  • Aging brain
  • Calcitonin
  • Extrapyramidal system

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Clementi, G., Prato, A., Bernardini, R., Nicoletti, F., Patti, F., De Simone, D., & Scapagnini, U. (1983). Effects of calcitonin on the brain of aged rats. Neurobiology of Aging, 4(3), 229-232. https://doi.org/10.1016/0197-4580(83)90025-8

Effects of calcitonin on the brain of aged rats. / Clementi, G.; Prato, A.; Bernardini, R.; Nicoletti, F.; Patti, F.; De Simone, D.; Scapagnini, U.

In: Neurobiology of Aging, Vol. 4, No. 3, 1983, p. 229-232.

Research output: Contribution to journalArticle

Clementi, G, Prato, A, Bernardini, R, Nicoletti, F, Patti, F, De Simone, D & Scapagnini, U 1983, 'Effects of calcitonin on the brain of aged rats', Neurobiology of Aging, vol. 4, no. 3, pp. 229-232. https://doi.org/10.1016/0197-4580(83)90025-8
Clementi G, Prato A, Bernardini R, Nicoletti F, Patti F, De Simone D et al. Effects of calcitonin on the brain of aged rats. Neurobiology of Aging. 1983;4(3):229-232. https://doi.org/10.1016/0197-4580(83)90025-8
Clementi, G. ; Prato, A. ; Bernardini, R. ; Nicoletti, F. ; Patti, F. ; De Simone, D. ; Scapagnini, U. / Effects of calcitonin on the brain of aged rats. In: Neurobiology of Aging. 1983 ; Vol. 4, No. 3. pp. 229-232.
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