Effects of calcitonin on the brain of aged rats

G. Clementi, A. Prato, R. Bernardini, F. Nicoletti, F. Patti, D. De Simone, U. Scapagnini

Research output: Contribution to journalArticlepeer-review

Abstract

We have recently demonstrated that calcitonin, a putative neuromodulator, may influence extrapyramidal motor system by decreasing nigro-striatal dopaminergic function. Since calcitonin is extensively used in aged patients, we have investigated whether calcitonin might influence extrapyramidal motor behavior (haloperidol-induced catalepsy and apomorphine-induced hyperactivity) in rats of different ages. Intracerebroventricular injection of salmon calcitonin (I μg/kg) prevented apomorphine-induced hyperactivity in 2, 7, 18 or 21 month old rats, but potentiated haloperidol-induced catalepsy only in 2 or 7 month old rats. In addition, in all the animals salmon calcitonin significantly decreased the secretion of prolactin, an anterior pituitary hormone that may act at central level enhancing nigro-striatal dopaminergic activity.

Original languageEnglish
Pages (from-to)229-232
Number of pages4
JournalNeurobiology of Aging
Volume4
Issue number3
DOIs
Publication statusPublished - 1983

Keywords

  • Aging brain
  • Calcitonin
  • Extrapyramidal system

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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