Effects of candesartan on left ventricular function, aldosterone and BNP in chronic heart failure

Aneta Aleksova, Serge Masson, Aldo P. Maggioni, Donata Lucci, Renato Urso, Lidia Staszewsky, Stefano Ciaffoni, Giuseppe Cacciatore, Gianfranco Misuraca, Michele Gulizia, Lucio Mos, Gianni Proietti, Calogero Minneci, Roberto Latini, Gianfranco Sinagra

Research output: Contribution to journalArticle

Abstract

Purpose Heart failure (HF) is characterized by activation of neurohormonal systems such as aldosterone and natriuretic peptides. In the absence of published data, CandHeart trial was designed to assess the effects on left ventricular (LV) function, aldosterone and brain natriuretic peptide (BNP) of candesartan in patients with HF and preserved (LVEF ≥ 40%) or depressed (LVEF

Original languageEnglish
Pages (from-to)131-143
Number of pages13
JournalCardiovascular Drugs and Therapy
Volume26
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Aldosterone
  • Candesartan
  • Heart failure
  • Left ventricular ejection fraction
  • Natriuretic peptide

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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    Aleksova, A., Masson, S., Maggioni, A. P., Lucci, D., Urso, R., Staszewsky, L., Ciaffoni, S., Cacciatore, G., Misuraca, G., Gulizia, M., Mos, L., Proietti, G., Minneci, C., Latini, R., & Sinagra, G. (2012). Effects of candesartan on left ventricular function, aldosterone and BNP in chronic heart failure. Cardiovascular Drugs and Therapy, 26(2), 131-143. https://doi.org/10.1007/s10557-012-6370-8