Effects of cardiac resynchronization therapy on the mechanisms underlying functional mitral regurgitation in congestive heart failure

Maria Cristina Porciani, Roberto Macioce, Gabriele Demarchi, Marco Chiostri, Nicola Musilli, Francesco Cappelli, Alessio Lilli, Giuseppe Ricciardi, Luigi Padeletti

Research output: Contribution to journalArticle

Abstract

Aims: Functional mitral regurgitation (FMR) improvement induced by cardiac resynchronization therapy (CRT) has been related to left ventricular (LV) remodeling reversal and contractility enhancement. The effects induced by the changes of LV synchronicity indexes on FMR severity have not been investigated. Methods and results: In 30 patients with CRT for heart failure (HF) and QRS > 130 ms, LV function parameters, FMR severity as mitral jet regurgitation/left atrial area ratio (JA/LAA) and standard deviation (SD) of the time to the systolic peak velocity at 6-basal and mid-LV segments as asynchrony indexes were evaluated (echo/tissue Doppler) before and 6 months after implant. At follow-up, 15 patients resulted responders to LV reverse remodeling with ≥15% end-systolic volume (ESV) and LV systolic function improvement. Improvement of FMR with ≥15% JA/LAA reduction was observed in 19 patients, 7 were nonresponders to LV reverse remodeling. In patients with ≥15% JA/LAA reduction a significant decrease of LV asynchrony indexes was observed as compared to patients without ≥15% JA/LAA reduction in whom LV asynchrony indexes were increased. Reduction of LV mid-segmental asynchrony was the variable most strongly related to JA/LAA reduction (r2 = 0.697, P

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalEuropean Journal of Echocardiography
Volume7
Issue number1
DOIs
Publication statusPublished - Jan 2006

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Cardiac Resynchronization Therapy
Mitral Valve Insufficiency
Heart Failure
Ventricular Remodeling
Left Ventricular Function

Keywords

  • Cardiac resynchronization therapy
  • Functional mitral regurgitation
  • Left ventricular remodeling reversal
  • Left ventricular synchronicity
  • Tissue Doppler imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of cardiac resynchronization therapy on the mechanisms underlying functional mitral regurgitation in congestive heart failure. / Porciani, Maria Cristina; Macioce, Roberto; Demarchi, Gabriele; Chiostri, Marco; Musilli, Nicola; Cappelli, Francesco; Lilli, Alessio; Ricciardi, Giuseppe; Padeletti, Luigi.

In: European Journal of Echocardiography, Vol. 7, No. 1, 01.2006, p. 31-39.

Research output: Contribution to journalArticle

Porciani, MC, Macioce, R, Demarchi, G, Chiostri, M, Musilli, N, Cappelli, F, Lilli, A, Ricciardi, G & Padeletti, L 2006, 'Effects of cardiac resynchronization therapy on the mechanisms underlying functional mitral regurgitation in congestive heart failure', European Journal of Echocardiography, vol. 7, no. 1, pp. 31-39. https://doi.org/10.1016/j.euje.2005.03.008
Porciani, Maria Cristina ; Macioce, Roberto ; Demarchi, Gabriele ; Chiostri, Marco ; Musilli, Nicola ; Cappelli, Francesco ; Lilli, Alessio ; Ricciardi, Giuseppe ; Padeletti, Luigi. / Effects of cardiac resynchronization therapy on the mechanisms underlying functional mitral regurgitation in congestive heart failure. In: European Journal of Echocardiography. 2006 ; Vol. 7, No. 1. pp. 31-39.
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