Influenza della cardiomegalia sullo stato anatomico e funzionale del polmone nello scompenso cardiaco cronico.

Translated title of the contribution: Effects of cardiomegaly on the anatomical and functional state of the lung in chronic heart failure

Research output: Contribution to journalArticlepeer-review

Abstract

Heart and lungs might compete for the intrathoracic space in case of heart enlargement (as in heart failure). Therefore, the pulmonary abnormalities observed in patients with chronic heart failure (restrictive pattern and reduction of diffusion capacity) might be at least in part related to cardiomegaly. In 53 patients (11 women, 42 men, mean age 65 +/- 8 years) with stable heart failure and cardiac enlargement (cardiothoracic ratio-Ctr > or = 50%) we measured carbon monoxide lung diffusion (DLCO), lung tissue content (VT, single breath, expiratory regression of acetylene), alveolar volume (Va, single breath, expiratory regression of methane) and vital capacity (VC). In 16 patients the two subcomponents of DLCO, i.e. alveolar-capillary membrane diffusion (Dm) and diffusion related to capillary volume (Cv), were analyzed. Patients were grouped for Ctr (> or = 60%, Group 1, n = 28 and <60%, Group 2, n = 25): VT (Group 1 0.62 +/- 0.2 l; Group 2 0.76 +/- 0.2 l, p <0.01); Va (Group 1 4.21 +/- 0.97 l; Group 2 5.37 +/- 1.12 l, p <0.0001); VC (Group 1 2.3 +/- 0.6 l; Group 2 3.1 +/- 0.6 l, p <0.0001); DLCO (Group 1 16.15 +/- 3.95 ml/min x mmHg; Group 2 22.24 +/- 6.57 ml/min x mmHg, p <0.0001). An inverse correlation was observed between Dm and Ctr (r = -0.47, p <0.02), which disappeared when Va was accounted for Dm/Va (r = -0.12, NS). Cv was lower in Group 1 vs Group 2. In conclusion, in patients with Ctr > or = 60% (Group 1) "anatomy" (VT, Va, VC and Cv) and function (DLCO) of the lungs are impeded. This is likely due to reduction of space available for the lungs in the thorax by an enlarged heart (no correlation between Dm/Va vs Ctr).

Translated title of the contributionEffects of cardiomegaly on the anatomical and functional state of the lung in chronic heart failure
Original languageItalian
Pages (from-to)295-301
Number of pages7
JournalCardiologia
Volume43
Issue number3
Publication statusPublished - Mar 1998

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Effects of cardiomegaly on the anatomical and functional state of the lung in chronic heart failure'. Together they form a unique fingerprint.

Cite this