Effects of C/EBPα and C/EBPβ in BCR/ABL-expressing cells: Differences and similarities

Clara Guerzoni, Giovanna Ferrari-Amorotti, Michela Bardini, Samanta A. Mariani, Bruno Calabretta

Research output: Contribution to journalArticle

Abstract

C/EBPα and C/EBPβ, two transcription factors of the C/EBP family play important roles in the proliferation and differentiation of various cell types including myeloid progenitors. Expression of C/EBPα and C/EBPβ is repressed in myeloid blast crisis of Chronic Myelogenous Leukemia by mechanisms that involve translation repression which depends on the interaction of RNA-binding proteins with conserved binding sites in the 5′UTR of c/ebpα and c/ebpβ mRNA. Ectopic expression of C/EBPα and C/EBPβ in myeloid progenitors expressing the BCR/ABL oncogene inhibits proliferation, induces differentiation and suppresses leukemogenesis in mice, but C/EBPα is markedly more effective than C/EBPβ. The more potent effects of C/EBPα probably depends on protein-protein interaction with cell-cycle regulatory proteins, but the pattern of genes modulated by C/EBPα and C/EBPβ is not completely overlapping. This suggests that transcription-dependent and -independent effects are both involved and support the therapeutic potential of reactivating C/EBPα and C/EBPβ expression in leukemic cells.

Original languageEnglish
Pages (from-to)1254-1257
Number of pages4
JournalCell Cycle
Volume5
Issue number12
Publication statusPublished - Jun 15 2006

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Keywords

  • Cell cycle
  • Differentiation
  • Leukemia
  • Transcription factor
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Cite this

Guerzoni, C., Ferrari-Amorotti, G., Bardini, M., Mariani, S. A., & Calabretta, B. (2006). Effects of C/EBPα and C/EBPβ in BCR/ABL-expressing cells: Differences and similarities. Cell Cycle, 5(12), 1254-1257.