Effects of celiprolol on reflex control of the cardiovascular system in essential hypertension

Giuseppe Mancia, Guido Grassi, Gianfranco Parati, Guido Pomidossi, Ettore Sabadini, Cristina Giannattasio, Gianbattista Bolla, Alberto Zanchetti

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously shown that baroreceptor control of the cardiovascular system and the cardiopulmonary receptor control of peripheral circulation are preserved or only moderately reduced during antihypertensive treatment with acebutolol or nadolol, which indicates that treatment with beta blockers with or without intrinsic sympathomimetic activity does not impair fundamental neural mechanisms involved in circulatory homeostasis. In the present study we have investigated the reflex control of circulation before and during antihypertensive treatment with celiprolol, which, in addition to its beta-blocking action, has vasodilator properties that may stem from interference with neural cardiovascular control. In six essential hypertensive subjects we measured blood pressure (intraarterial catheter), heart rate (ECG recording), central venous pressure (right atrial catheter), and forearm blood flow and resistance (plethysmography) before and during alterations in the activity of the arterial baroreceptors obtained by means of lower body suction and passive leg raising. The study was performed before and after 5-7 days of oral administration of celiprolol at 200-400 mg once a day. Compared to the values obtained in the control, condition celiprolol caused a reduction in blood pressure, a slight change in heart rate, and an increase in forearm blood flow, which indicated the occurrence of a clear-cut forearm vasodilatation. The heart rate responses to arterial baroreceptor manipulation were unchanged by celiprolol which reset the carotid baroflex so that its tonic restraint on blood pressure increased despite the hypotension induced by the drug. The inhibitory restraint tonically exerted by the cardiopulmonary receptors on peripheral circulation was also increased by celiprolol. These findings show that in contrast with many beta blockers, celiprolol causes a forearm vasodilatation in hypertensive humans. The baroreceptor and cardiopulmonary receptor control of the cardiovascular system is not impaired and may even be enhanced by the drug. This ensures that, regardless of its mechanisms of action, celiprolol does not adversely affect circulatory homeostasis.

Original languageEnglish
Pages (from-to)S67-S74
JournalJournal of Cardiovascular Pharmacology
Volume8
Publication statusPublished - 1986

Keywords

  • Alpha receptors
  • Arterial baroreceptors
  • Beta blockade
  • Cardiopulmonary receptors
  • Catecholamines
  • Forearm circulation
  • Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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