Effects of Cerebral Perfusion Pressure on Brain Tissue PO2 in Patients with Severe Head Injury

Paola Bruzzone, R. Dionigi, G. Bellinzona, R. Imberti, N. Stocchetti

Research output: Contribution to journalArticlepeer-review


Ischemia causes secondary brain damage after severe head injury (SHI). Cerebral perfusion is commonly estimated by monitoring CPP, but the adequacy of cerebral oxygenation requires further measurements, such as jugular oxygen saturation or, more recently, PtiO2 monitoring. In 7 patients with severe head injury, ICP, MAP, CPP, SjO2 and PtiO2 were monitored for a mean time of 9.0 ± 2.2 days. Most of the data were in a "normal" range. Focusing on values under the thresholds of 60mm Hg for CPP and 20mm Hg for PtiO2, we found a relationship between CPP and PtiO2. Looking at the PtiO2 time-course, we observed a quite constant increasing trend during the first 48 hours of monitoring, then the values remained relatively constant within a normal range. Our data show that decreases of PtiO2 are not uncommon after severe head injury and therefore it seems that monitoring of PtiO2 in SHI may be useful in order to minimize secondary insults.

Original languageEnglish
Pages (from-to)111-113
Number of pages3
JournalActa Neurochirurgica, Supplement
Issue numberSUPPL. 71
Publication statusPublished - 1998


  • Brain tissue PO
  • Cerebral perfusion pressure
  • CPP
  • ICP
  • Jugular oxygen saturation
  • Severe head injury

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology


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