Abstract
The effect of antineoplastic agents on immune responses is heterogenous. Moreover, the immunomodulators usually employed in experimental and clinical studies seem to act differentially on humoral and cellular immune functions and on the cell-subpopulations involved in these functions. Thus, taking into account the different activities of immunodepressive and immunostimulant agents, a rationale can be developed in drawing experimental immunotherapeutic protocols. The results obtained combining several antineoplastic drugs (Adriamycin, Cyclophosphamide, 5-Fluorouracil, Daunomycin) and several immunomodulators (Corynebacterium parvum, BCG and Levamisole) are summarized. The experimental data show that the best therapeutic activity can be achieved with those combinations (Adriamycin - C. parvum and Cyclophosphamide C. parvum) that were expected to give a synergistic effect from the basic data previously obtained.
| Original language | English |
|---|---|
| Pages (from-to) | 83-92 |
| Number of pages | 10 |
| Journal | Chemioterapia Oncologica |
| Volume | 4 |
| Issue number | 2 |
| Publication status | Published - 1980 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Effects of chemotherapeutic agents and immunomodulators on host defense mechanisms : a basis for less empirical chemoimmunotherapy approaches. / Mantovani, A.; Tagliabue, A.; Vecchi, A.
In: Chemioterapia Oncologica, Vol. 4, No. 2, 1980, p. 83-92.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of chemotherapeutic agents and immunomodulators on host defense mechanisms
T2 - a basis for less empirical chemoimmunotherapy approaches
AU - Mantovani, A.
AU - Tagliabue, A.
AU - Vecchi, A.
PY - 1980
Y1 - 1980
N2 - The effect of antineoplastic agents on immune responses is heterogenous. Moreover, the immunomodulators usually employed in experimental and clinical studies seem to act differentially on humoral and cellular immune functions and on the cell-subpopulations involved in these functions. Thus, taking into account the different activities of immunodepressive and immunostimulant agents, a rationale can be developed in drawing experimental immunotherapeutic protocols. The results obtained combining several antineoplastic drugs (Adriamycin, Cyclophosphamide, 5-Fluorouracil, Daunomycin) and several immunomodulators (Corynebacterium parvum, BCG and Levamisole) are summarized. The experimental data show that the best therapeutic activity can be achieved with those combinations (Adriamycin - C. parvum and Cyclophosphamide C. parvum) that were expected to give a synergistic effect from the basic data previously obtained.
AB - The effect of antineoplastic agents on immune responses is heterogenous. Moreover, the immunomodulators usually employed in experimental and clinical studies seem to act differentially on humoral and cellular immune functions and on the cell-subpopulations involved in these functions. Thus, taking into account the different activities of immunodepressive and immunostimulant agents, a rationale can be developed in drawing experimental immunotherapeutic protocols. The results obtained combining several antineoplastic drugs (Adriamycin, Cyclophosphamide, 5-Fluorouracil, Daunomycin) and several immunomodulators (Corynebacterium parvum, BCG and Levamisole) are summarized. The experimental data show that the best therapeutic activity can be achieved with those combinations (Adriamycin - C. parvum and Cyclophosphamide C. parvum) that were expected to give a synergistic effect from the basic data previously obtained.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019258374&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0019258374
VL - 4
SP - 83
EP - 92
JO - Chemioterapia Oncologica
JF - Chemioterapia Oncologica
SN - 0392-0968
IS - 2
ER -