Effects of chronic carotid baroreceptor activation on arterial stiffness in severe heart failure

Edoardo Gronda, Gianmaria Brambilla, Gino Luciano Seravalle, Alessandro Maloberti, Matteo Cairo, Giuseppe Costantino, Eric G. Lovett, Emilio Vanoli, Giuseppe Mancia, Guido Grassi

Research output: Contribution to journalArticlepeer-review


Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by activation of the sympathetic nervous system and increased arterial stiffness, leading to an impaired ventricular-vascular coupling. Baroreflex activation therapy (BAT) has been shown to reduce muscle sympathetic nerve activity (MSNA) and improve clinical status of patients with HFrEF. The purpose of this investigation was to determine the effects of BAT on arterial stiffness in HFrEF. Methods and results: MSNA, clinical variables, and parameters of central blood pressure (BP) and arterial stiffness were collected in 18 NYHA Class III HFrEF patients, nine receiving BAT and nine continuing with optimal medical management alone. Patients were followed for 3 months, with measurements at that time compared to baseline evaluation. Baseline characteristics of the groups were well matched. At 3 months, BAT did not improve central BP and arterial stiffness despite a significant amelioration of MSNA, NYHA class, Minnesota living with heart failure questionnaire score, number of heart failure medications and six-minute walking distance. The control group exhibited no significant changes in all the measured variables. Conclusions: Despite significant reductions in MSNA and clinical improvement, BAT does not appear to chronically modify arterial stiffness within this HFrEF cohort. Additional study is required to determine if this result applies to the HFrEF population as a whole.

Original languageEnglish
Pages (from-to)838-846
Number of pages9
JournalClinical Research in Cardiology
Issue number10
Publication statusPublished - Oct 1 2016


  • Arterial stiffness
  • Baroreflex activation therapy
  • Central blood pressure
  • Congestive heart failure
  • Pulse wave velocity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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