Effects of chronic cilazapril treatment on cardiovascular control: A spectral analytical approach

M. Pagani, P. Pizzinelli, P. Mariani, D. Lucini, R. Di Michele, A. Malliani

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In 11 subjects with mild hypertension (sitting arterial pressure of 146 ± 5/97 ± 2 mm Hg), the effects of chronic angiotensin-converting enzyme (ACE) inhibition (cilazapril, 5 mg p.o. once daily for 4 weeks) were studied at rest and during active standing by means of spectral analysis. Sympathetic vascular control was inferred from the power of the low-frequency (LF) component of the systolic arterial pressure (SAP) variability, assessed noninvasively with a plethysmographic technique. Simultaneously, quantitative indices of neural control of the sinoatrial (SA) node were obtained with the power of the LF and of the high-frequency (respiration linked) component of R-R variability. Before treatment, active standing produced a clear increase in the LF components of R-R and SAP variabilities. At the end of the 4 weeks of cilazapril treatment, the LF component of SAP variability during standing was significantly lower than prior to treatment, while the increase in the LF component of R-R variability was left unchanged. These findings suggest an inhibitory effect of chronic ACE inhibition upon vasomotor sympathetic control, as assessed noninvasively by this technique.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
Issue numberSUPPL. 6
Publication statusPublished - 1992


  • ACE inhibition
  • Hypertension
  • Spectral analysis
  • Sympathetic activity
  • Vasomotion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology


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